PDB entry 4rqv

View 4rqv on RCSB PDB site
Description: Crystal structure of PDK1 in complex with ATP and the PIF-pocket ligand RS2
Class: transferase/transferase inhibitor
Keywords: Protein Kinase, Phosphorylation, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2014-11-05, released 2014-12-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-phosphoinositide-dependent protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK1, PDPK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15530 (Start-310)
      • engineered mutation (239)
      • engineered mutation (243)
    Domains in SCOPe 2.08: d4rqva_
  • Heterogens: GOL, ATP, R2S, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4rqvA (A:)
gamdgtaaeprpgagslqhaqpppqprkkrpedfkfgkilgegsfstvvlarelatsrey
aikilekrhiikenkvpyvtrerdvmsrldhpffvklyftfqddeklyfglsyakngell
kyirkigsfdetctrfytaeivsaleylhgkgiihrdlkpenillnedmhiqitdfgtak
vlspeskqaransfvgtaqyvspellteksackssdlwalgciiyqlvaglppfragneg
lifakiikleydfpekffpkardlvekllvldatkrlgceemegygplkahpffesvtwe
nlhqqtppklt

    Sequence, based on observed residues (ATOM records): (download) 
    >4rqvA (A:)
ppqprkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtre
rdvmsrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeiv
saleylhgkgiihrdlkpenillnedmhiqitdfgtakvlspeskqaransfvgtaqyvs
pellteksackssdlwalgciiyqlvaglppfragneglifakiikleydfpekffpkar
dlvekllvldatkrlgceemegygplkahpffesvtwenlhqqtppklt