PDB entry 4rqq

View 4rqq on RCSB PDB site
Description: Crystal structure of human Fab PGDM1400, a broadly reactive and potent HIV-1 neutralizing antibody
Class: immune system
Keywords: IgG, anti-HIV-1 antibody, HIV-1 Env trimer, IMMUNE SYSTEM
Deposited on 2014-11-04, released 2014-11-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-12-24, with a file datestamp of 2014-12-19.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.223
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Human anti-HIV-1 antibody PGDM1400 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4RQQ
    Domains in SCOPe 2.08: d4rqqa1, d4rqqa2
  • Chain 'B':
    Compound: Human anti-HIV-1 antibody PGDM1400 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4RQQ
    Domains in SCOPe 2.08: d4rqqb_
  • Chain 'C':
    Compound: Human anti-HIV-1 antibody PGDM1400 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4RQQ
    Domains in SCOPe 2.08: d4rqqc1, d4rqqc2
  • Chain 'D':
    Compound: Human anti-HIV-1 antibody PGDM1400 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4RQQ
    Domains in SCOPe 2.08: d4rqqd_
  • Chain 'H':
    Compound: Human anti-HIV-1 antibody PGDM1400 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4RQQ
    Domains in SCOPe 2.08: d4rqqh_
  • Chain 'L':
    Compound: Human anti-HIV-1 antibody PGDM1400 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4RQQ
    Domains in SCOPe 2.08: d4rqql1, d4rqql2

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4rqqA (A:)
dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassra
sgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >4rqqA (A:)
vltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassrasg
vpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikrtvaapsvfi
fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslss
tltlskadyekhkvyacevthqglsspvtksfnrg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4rqqB (B:)
qaqlvqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkvi
verfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalydddgalnwav
dvdylsnlefwgqgtavtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtv
swnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve
pkscd

    Sequence, based on observed residues (ATOM records): (download) 
    >4rqqB (B:)
qlvqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkvive
rfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalydddgalnwavdv
dylsnlefwgqgtavtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvsw
nsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4rqqC (C:)
dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassra
sgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >4rqqC (C:)
vltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassrasg
vpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikrtvaapsvfi
fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslss
tltlskadyekhkvyacevthqglsspvtksfn

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4rqqD (D:)
qaqlvqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkvi
verfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalydddgalnwav
dvdylsnlefwgqgtavtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtv
swnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve
pkscd

    Sequence, based on observed residues (ATOM records): (download) 
    >4rqqD (D:)
qlvqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkvive
rfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalydddgalnwavdv
dylsnlefwgqgtavtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvsw
nsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4rqqH (H:)
qaqlvqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkvi
verfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalydddgalnwav
dvdylsnlefwgqgtavtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtv
swnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve
pkscd

    Sequence, based on observed residues (ATOM records): (download) 
    >4rqqH (H:)
qlvqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkvive
rfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalydddgalnwavdv
dylsnlefwgqgtavtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvsw
nsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk
s

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >4rqqL (L:)
dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassra
sgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >4rqqL (L:)
vltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassrasg
vpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikrtvaapsvfi
fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslss
tltlskadyekhkvyacevthqglsspvtksfnrg