PDB entry 4rm5

View 4rm5 on RCSB PDB site
Description: Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins
Class: hydrolase
Keywords: hydrolysis of beta-lactam antibiotics, HYDROLASE
Deposited on 2014-10-19, released 2014-11-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-11-19, with a file datestamp of 2014-11-14.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.161
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-lactamase NDM-1
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaNDM-1
    Database cross-references and differences (RAF-indexed):
    • Uniprot C7C422 (Start-241)
      • engineered mutation (95)
    Domains in SCOPe 2.08: d4rm5a_
  • Chain 'B':
    Compound: Beta-lactamase NDM-1
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaNDM-1
    Database cross-references and differences (RAF-indexed):
    • Uniprot C7C422
      • engineered mutation (95)
    Domains in SCOPe 2.08: d4rm5b_
  • Chain 'C':
    Compound: Beta-lactamase NDM-1
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaNDM-1
    Database cross-references and differences (RAF-indexed):
    • Uniprot C7C422
      • engineered mutation (95)
    Domains in SCOPe 2.08: d4rm5c_
  • Chain 'D':
    Compound: Beta-lactamase NDM-1
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaNDM-1
    Database cross-references and differences (RAF-indexed):
    • Uniprot C7C422 (Start-241)
      • engineered mutation (95)
    Domains in SCOPe 2.08: d4rm5d_
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4rm5A (A:)
geirptigqqmetgdqrfgdlvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlv
vdtawtddqtaqilnwikqeinlpvalavvthahqnkmggmdalhaagiatyanalsnql
apqegmvaaqhsltfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggc
likdskakslgnlgdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadk
lr

    Sequence, based on observed residues (ATOM records): (download) 
    >4rm5A (A:)
tgdqrfgdlvfrqlapnvwqhtsyldmavasnglivrdggrvlvvdtawtddqtaqilnw
ikqeinlpvalavvthahqnkmggmdalhaagiatyanalsnqlapqegmvaaqhsltfa
angwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclikdskakslgnlgda
dtehyaasarafgaafpkasmivmshsapdsraaithtarmadklr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4rm5B (B:)
geirptigqqmetgdqrfgdlvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlv
vdtawtddqtaqilnwikqeinlpvalavvthahqnkmggmdalhaagiatyanalsnql
apqegmvaaqhsltfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggc
likdskakslgnlgdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadk
lr

    Sequence, based on observed residues (ATOM records): (download) 
    >4rm5B (B:)
dqrfgdlvfrqlapnvwqhtsylgavasnglivrdggrvlvvdtawtddqtaqilnwikq
einlpvalavvthahqnkmggmdalhaagiatyanalsnqlapqegmvaaqhsltfaang
wvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclikdskakslgnlgdadte
hyaasarafgaafpkasmivmshsapdsraaithtarmadkl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4rm5C (C:)
geirptigqqmetgdqrfgdlvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlv
vdtawtddqtaqilnwikqeinlpvalavvthahqnkmggmdalhaagiatyanalsnql
apqegmvaaqhsltfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggc
likdskakslgnlgdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadk
lr

    Sequence, based on observed residues (ATOM records): (download) 
    >4rm5C (C:)
dqrfgdlvfrqlapnvwqhtsyldmavasnglivrdggrvlvvdtawtddqtaqilnwik
qeinlpvalavvthahqnkmggmdalhaagiatyanalsnqlapqegmvaaqhsltfaan
gwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclikdskakslgnlgdadt
ehyaasarafgaafpkasmivmshsapdsraaithtarmadkl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4rm5D (D:)
geirptigqqmetgdqrfgdlvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlv
vdtawtddqtaqilnwikqeinlpvalavvthahqnkmggmdalhaagiatyanalsnql
apqegmvaaqhsltfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggc
likdskakslgnlgdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadk
lr

    Sequence, based on observed residues (ATOM records): (download) 
    >4rm5D (D:)
gdqrfgdlvfrqlapnvwqhtsyldvasnglivrdggrvlvvdtawtddqtaqilnwikq
einlpvalavvthahqnkmggmdalhaagiatyanalsnqlapqegmvaaqhsltfaang
wvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclikdskakslgnlgdadte
hyaasarafgaafpkasmivmshsapdsraaithtarmadklr