PDB entry 4rli

View 4rli on RCSB PDB site
Description: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A048
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: oxidoreductase, FMN binding, mitochondria inner membrane, inner membrane, oxidoreductase-oxidoreductase inhibitor complex
Deposited on 2014-10-17, released 2015-11-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-17, with a file datestamp of 2019-07-12.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4rlia_
  • Heterogens: FMN, ORO, 3SH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4rliA (A:)
mghhhhhhhhhhssghiddddkhmatgderfyaehlmptlqglldpesahrlavrftslg
llprarfqdsdmlevrvlghkfrnpvgiaagfdkhgeavdglykmgfgfveigsvtpkpq
egnprprvfrlpedqavinrygfnshglsvvehrlrarqqkqakltedglplgvnlgknk
tsvdaaedyaegvrvlgpladylvvnvsspntaglrslqgkaelrrlltkvlqerdglrr
vhrpavlvkiapdltsqdkediasvvkelgidglivtnttvsrpaglqgalrsetgglsg
kplrdlstqtiremyaltqgrvpiigvggvssgqdalekiragaslvqlytaltfwgppv
vgkvkreleallkeqgfggvtdaigadhrr

    Sequence, based on observed residues (ATOM records): (download) 
    >4rliA (A:)
lqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpvgiaagfdkhgeav
dglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshglsvvehrlrarq
qkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvsspntaglrslq
gkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelgidglivtnt
tvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggvssgqdalek
iragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhr