PDB entry 4rix

View 4rix on RCSB PDB site
Description: Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-Q790R mutation
Class: transferase
Keywords: receptor tyrosine kinase, pseudokinase, kinase, ATP binding, membrane, transferase
Deposited on 2014-10-07, released 2014-12-10
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-12-17, with a file datestamp of 2014-12-12.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.21
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Receptor tyrosine-protein kinase erbB-3
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB3, HER3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21860
      • engineered mutation (114)
    Domains in SCOPe 2.06: d4rixa_
  • Chain 'B':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (270)
    Domains in SCOPe 2.06: d4rixb_
  • Chain 'C':
    Compound: Receptor tyrosine-protein kinase erbB-3
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB3, HER3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21860
      • engineered mutation (114)
    Domains in SCOPe 2.06: d4rixc_
  • Chain 'D':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (270)
    Domains in SCOPe 2.06: d4rixd_
  • Heterogens: ANP, MG, ADP

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4rixA (A:)
gagkvlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviedksgrqsfq
avtdhmlaigsldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgprlllnw
gvqiakgmyyleehgmvhrnlaarnvllkspsqvqvadfgvadllppddkqllyseaktp
ikwmalesihfgkythqsdvwsygvtvwelmtfgaepyaglrlaevpdllekgerlaqpq
ictidvymvmvkcwmidenirptfkelaneftrmardpprylvikresgpgiapgpephg
ltnkkleevelepeldldldleaeed

    Sequence, based on observed residues (ATOM records): (download) 
    >4rixA (A:)
vlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviedksgrqsfqavtd
hmlaigsldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgprlllnwgvqi
akgmyyleehgmvhrnlaarnvllkspsqvqvadfgvadllpppikwmalesihfgkyth
qsdvwsygvtvwelmtfgaepyaglrlaevpdllekgerlaqpqictidvymvmvkcwmi
denirptfkelaneftrmardpprylvik

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4rixB (B:)
gamgllqerelvepltpsgeapnqallrilketefkkikvlgsgafgtvykglwipegek
vkipvaikelreatspkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgc
lldyvrehkdnigsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfg
lakllgaeekeyhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydg
ipaseissilekgerlpqppictidvymimrkcwmidadsrpkfreliiefskmardpqr
ylviqgdermhlpsptdsnayraamdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >4rixB (B:)
lvepltpsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikel
reatspkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkd
nigsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeek
eyhavpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekge
rlpqppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4rixC (C:)
gagkvlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviedksgrqsfq
avtdhmlaigsldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgprlllnw
gvqiakgmyyleehgmvhrnlaarnvllkspsqvqvadfgvadllppddkqllyseaktp
ikwmalesihfgkythqsdvwsygvtvwelmtfgaepyaglrlaevpdllekgerlaqpq
ictidvymvmvkcwmidenirptfkelaneftrmardpprylvikresgpgiapgpephg
ltnkkleevelepeldldldleaeed

    Sequence, based on observed residues (ATOM records): (download) 
    >4rixC (C:)
vlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviesfqavtdhmlaig
sldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgprlllnwgvqiakgmyy
leehgmvhrnlaarnvllkspsqvqvadfgvadllppddkqllyseaktpikwmalesih
fgkythqsdvwsygvtvwelmtfgaepyaglrlaevpdllekgerlaqpqictidvymvm
vkcwmidenirptfkelaneftrmardpprylvik

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4rixD (D:)
gamgllqerelvepltpsgeapnqallrilketefkkikvlgsgafgtvykglwipegek
vkipvaikelreatspkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgc
lldyvrehkdnigsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfg
lakllgaeekeyhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydg
ipaseissilekgerlpqppictidvymimrkcwmidadsrpkfreliiefskmardpqr
ylviqgdermhlpsptdsnayraamdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >4rixD (D:)
lvepltpsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikel
reatspkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkd
nigsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeek
eyhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissil
ekgerlpqppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgd