PDB entry 4re1

View 4re1 on RCSB PDB site
Description: Crystal structure of human TEAD1 and disulfide-engineered YAP
Class: transcription/protein binding
Keywords: immunoglobulin-like fold, Transcription regulation, DNA-binding, protein-protein interaction, phosphoprotein, nucleus, TRANSCRIPTION-PROTEIN BINDING complex
Deposited on 2014-09-21, released 2014-11-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-09-02, with a file datestamp of 2015-08-28.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transcriptional enhancer factor TEF-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TEAD1, TCF13, TEF1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4re1a_
  • Chain 'B':
    Compound: Transcriptional enhancer factor TEF-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TEAD1, TCF13, TEF1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4re1b_
  • Chain 'C':
    Compound: Yorkie homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: YAP1, YAP65
    Database cross-references and differences (RAF-indexed):
    • Uniprot P46937 (27-End)
      • engineered mutation (64)
      • engineered mutation (70)
      • engineered mutation (73)
  • Chain 'D':
    Compound: Yorkie homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: YAP1, YAP65
    Database cross-references and differences (RAF-indexed):
    • Uniprot P46937
      • engineered mutation (64)
      • engineered mutation (70)
      • engineered mutation (73)
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4re1A (A:)
marsigttklrlvefsafleqqrdpdsynkhlfvhighanhsysdpllesvdirqiydkf
pekkgglkelfgkgpqnafflvkfwadlncniqddagafygvtsqyessenmtvtcstkv
csfgkqvvekveteyarfengrfvyrinrspmceyminfihklkhlpekymmnsvlenft
illvvtnrdtqetllcmacvfevsnsehgaqhhiyrlvkd

    Sequence, based on observed residues (ATOM records): (download) 
    >4re1A (A:)
rsigttklrlvefsafleqqrdpdsynkhlfvhighpllesvdirqiydkfpekkgglke
lfgkgpqnafflvkfwadlncngafygvtsqyessenmtvtcstkvcsfgkqvvekvete
yarfengrfvyrinrspmceyminfihklkhlpekymmnsvlenftillvvtnrdtqetl
lcmacvfevsnsehgaqhhiyrlvkd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4re1B (B:)
marsigttklrlvefsafleqqrdpdsynkhlfvhighanhsysdpllesvdirqiydkf
pekkgglkelfgkgpqnafflvkfwadlncniqddagafygvtsqyessenmtvtcstkv
csfgkqvvekveteyarfengrfvyrinrspmceyminfihklkhlpekymmnsvlenft
illvvtnrdtqetllcmacvfevsnsehgaqhhiyrlvkd

    Sequence, based on observed residues (ATOM records): (download) 
    >4re1B (B:)
rsigttklrlvefsafleqqrdpdsynkhlfvhigllesvdirqiydkfpekkgglkelf
gkgpqnafflvkfwadlncngafygvtsqyessenmtvtcstkvcsfgkqvvekveteya
rfengrfvyrinrspmceyminfihklkhlpekymmnsvlenftillvvtnrdtqetllc
macvfevsnsgaqhhiyrlvkd

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.