PDB entry 4rce
View 4rce on RCSB PDB site
Description: Crystal structure of BACE1 in complex with aminooxazoline xanthene inhibitor 2
Class: Hydrolase/Hydrolase inhibitor
Keywords: aspartic protease, Alzheimer's disease, APP, amyloid precursor protein, brain, Hydrolase-Hydrolase inhibitor complex
Deposited on
2014-09-15, released
2014-12-24
The last revision prior to the SCOPe 2.08 freeze date was dated
2015-01-14, with a file datestamp of
2015-01-09.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.202
AEROSPACI score: 0.27
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Beta-secretase 1
Species: Homo sapiens [TaxId:9606]
Gene: BACE, BACE1, KIAA1149
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4rcea_ - Heterogens: 3LN, IOD, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4rceA (A:)
lpretdeepeepgkkgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavg
aaphpflhryyqrqlsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaa
itesdkffingsnwegilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfpl
nqsevlasvggsmiiggidhslytgslwytpirrewyyeviivrveingqdlkmdckeyn
ydksivdsgttnlrlpkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifp
vislylmgevtnqsfritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegf
yvvfdrarkrigfavsachvhdefrtaavegpfvtldmedcgynipqtdes
Sequence, based on observed residues (ATOM records): (download)
>4rceA (A:)
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgaasvggsmiiggidhslytgsl
wytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksi
kaasstekfpdgfwlgeqlvcwqwnifpvislylmgevtnqsfritilpqqylrpvdcyk
faisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaavegpfvtldmed
cgyn