PDB entry 4ram

View 4ram on RCSB PDB site
Description: Crystal Structure of New Delhi Metallo-beta-Lactamase-1 Mutant M67V Complexed with Hydrolyzed Penicillin G
Class: hydrolase/antibiotic
Keywords: Structural Genomics, PSI-Biology, Midwest Center for Structural Genomics, MCSG, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors, MTBI, alpha-beta-beta-alpha sandwich, hydrolase, HYDROLASE-ANTIBIOTIC complex
Deposited on 2014-09-10, released 2014-09-24
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-09-24, with a file datestamp of 2014-09-19.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: 0.145
AEROSPACI score: 0.59 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-lactamase NDM-1
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaNDM-1
    Database cross-references and differences (RAF-indexed):
    • Uniprot C7C422 (3-End)
      • engineered mutation (39)
    Domains in SCOPe 2.05: d4rama_
  • Chain 'B':
    Compound: Beta-lactamase NDM-1
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaNDM-1
    Database cross-references and differences (RAF-indexed):
    • Uniprot C7C422 (3-End)
      • engineered mutation (39)
    Domains in SCOPe 2.05: d4ramb_
  • Heterogens: ZN, PNM, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ramA (A:)
snairptigqqmetgdqrfgdlvfrqlapnvwqhtsyldvpgfgavasnglivrdggrvl
vvdtawtddqtaqilnwikqeinlpvalavvthahqdkmggmdalhaagiatyanalsnq
lapqegmvaaqhsltfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafgg
clikdskakslgnlgdadtehyaasarafgaafpkasmivmshsapdsraaithtarmad
klr

    Sequence, based on observed residues (ATOM records): (download) 
    >4ramA (A:)
irptigqqmetgdqrfgdlvfrqlapnvwqhtsyldvpgfgavasnglivrdggrvlvvd
tawtddqtaqilnwikqeinlpvalavvthahqdkmggmdalhaagiatyanalsnqlap
qegmvaaqhsltfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggcli
kdskakslgnlgdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadkl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ramB (B:)
snairptigqqmetgdqrfgdlvfrqlapnvwqhtsyldvpgfgavasnglivrdggrvl
vvdtawtddqtaqilnwikqeinlpvalavvthahqdkmggmdalhaagiatyanalsnq
lapqegmvaaqhsltfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafgg
clikdskakslgnlgdadtehyaasarafgaafpkasmivmshsapdsraaithtarmad
klr

    Sequence, based on observed residues (ATOM records): (download) 
    >4ramB (B:)
irptigqqmetgdqrfgdlvfrqlapnvwqhtsyldvpgfgavasnglivrdggrvlvvd
tawtddqtaqilnwikqeinlpvalavvthahqdkmggmdalhaagiatyanalsnqlap
qegmvaaqhsltfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggcli
kdskakslgnlgdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadkl