PDB entry 4r7u

View 4r7u on RCSB PDB site
Description: Structure of UDP-N-acetylglucosamine 1-carboxyvinyltransferase from Vibrio cholerae in complex with substrate UDP-N-acetylglucosamine and the drug fosfomycin
Class: transferase/antibiotic
Keywords: MURA, FOSFOMYCIN, PEPTIDOGLYCAN, AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM, PEPTIDOGLYCAN BIOSYNTHESIS, Structural Genomics, NIAID, National Institute of Allergy and Infectious Diseases, Center for Structural Genomics of Infectious Diseases, CSGID, UDP-N-acetylglucosamine 1-carboxyvinyltransferase, TRANSFERASE-ANTIBIOTIC complex
Deposited on 2014-08-28, released 2014-09-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
    Species: Vibrio cholerae O1 biovar El Tor str. N16961 [TaxId:243277]
    Gene: murA, VC_2514
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r7ua_
  • Chain 'B':
    Compound: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
    Species: Vibrio cholerae O1 biovar El Tor str. N16961 [TaxId:243277]
    Gene: murA, VC_2514
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r7ub_
  • Chain 'C':
    Compound: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
    Species: Vibrio cholerae O1 biovar El Tor str. N16961 [TaxId:243277]
    Gene: murA, VC_2514
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r7uc_
  • Chain 'D':
    Compound: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
    Species: Vibrio cholerae O1 biovar El Tor str. N16961 [TaxId:243277]
    Gene: murA, VC_2514
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r7ud_
  • Heterogens: PG4, FFQ, UD1, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4r7uA (A:)
snamekfrvigstqplqgevtisgaknaalpilfasilaeepvevanvphlrdidttmel
lerlgakverngsvhvdagpinqycapydlvktmrasiwalgplvarfgqgqvslpggca
igarpvdlhihgleqlgatitledgyvkahvdgrlqgahivmdkvsvgatitimcaatla
egttvldnaarepeivdtamflnklgakisgagtdsitiegverlgggkhavvpdrietg
tflvaaavsrgkivcrnthahlleavlakleeagaeiecgedwisldmtgrelkavtvrt
aphpgfptdmqaqftllnmmakgggvitetifenrfmhvpelkrmgakaeiegntvicgd
vdrlsgaqvmatdlrasaslviagciakgetivdriyhidrgyeriedklsalganierf
rd

    Sequence, based on observed residues (ATOM records): (download) 
    >4r7uA (A:)
mekfrvigstqplqgevtisgaknaalpilfasilaeepvevanvphlrdidttmeller
lgakverngsvhvdagpinqycapydlvktmrasiwalgplvarfgqgqvslpggcaiga
rpvdlhihgleqlgatitledgyvkahvdgrlqgahivmdkvsvgatitimcaatlaegt
tvldnaarepeivdtamflnklgakisgagtdsitiegverlgggkhavvpdrietgtfl
vaaavsrgkivcrnthahlleavlakleeagaeiecgedwisldmtgrelkavtvrtaph
pgfptdmqaqftllnmmakgggvitetifenrfmhvpelkrmgakaeiegntvicgdvdr
lsgaqvmatdlrasaslviagciakgetivdriyhidrgyeriedklsalganierfr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4r7uB (B:)
snamekfrvigstqplqgevtisgaknaalpilfasilaeepvevanvphlrdidttmel
lerlgakverngsvhvdagpinqycapydlvktmrasiwalgplvarfgqgqvslpggca
igarpvdlhihgleqlgatitledgyvkahvdgrlqgahivmdkvsvgatitimcaatla
egttvldnaarepeivdtamflnklgakisgagtdsitiegverlgggkhavvpdrietg
tflvaaavsrgkivcrnthahlleavlakleeagaeiecgedwisldmtgrelkavtvrt
aphpgfptdmqaqftllnmmakgggvitetifenrfmhvpelkrmgakaeiegntvicgd
vdrlsgaqvmatdlrasaslviagciakgetivdriyhidrgyeriedklsalganierf
rd

    Sequence, based on observed residues (ATOM records): (download) 
    >4r7uB (B:)
mekfrvigstqplqgevtisgaknaalpilfasilaeepvevanvphlrdidttmeller
lgakverngsvhvdagpinqycapydlvktmrasiwalgplvarfgqgqvslpggcaiga
rpvdlhihgleqlgatitledgyvkahvdgrlqgahivmdkvsvgatitimcaatlaegt
tvldnaarepeivdtamflnklgakisgagtdsitiegverlgggkhavvpdrietgtfl
vaaavsrgkivcrnthahlleavlakleeagaeiecgedwisldmtgrelkavtvrtaph
pgfptdmqaqftllnmmakgggvitetifenrfmhvpelkrmgakaeiegntvicgdvdr
lsgaqvmatdlrasaslviagciakgetivdriyhidrgyeriedklsalganierfr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4r7uC (C:)
snamekfrvigstqplqgevtisgaknaalpilfasilaeepvevanvphlrdidttmel
lerlgakverngsvhvdagpinqycapydlvktmrasiwalgplvarfgqgqvslpggca
igarpvdlhihgleqlgatitledgyvkahvdgrlqgahivmdkvsvgatitimcaatla
egttvldnaarepeivdtamflnklgakisgagtdsitiegverlgggkhavvpdrietg
tflvaaavsrgkivcrnthahlleavlakleeagaeiecgedwisldmtgrelkavtvrt
aphpgfptdmqaqftllnmmakgggvitetifenrfmhvpelkrmgakaeiegntvicgd
vdrlsgaqvmatdlrasaslviagciakgetivdriyhidrgyeriedklsalganierf
rd

    Sequence, based on observed residues (ATOM records): (download) 
    >4r7uC (C:)
mekfrvigstqplqgevtisgaknaalpilfasilaeepvevanvphlrdidttmeller
lgakverngsvhvdagpinqycapydlvktmrasiwalgplvarfgqgqvslpggcaiga
rpvdlhihgleqlgatitledgyvkahvdgrlqgahivmdkvsvgatitimcaatlaegt
tvldnaarepeivdtamflnklgakisgagtdsitiegverlgggkhavvpdrietgtfl
vaaavsrgkivcrnthahlleavlakleeagaeiecgedwisldmtgrelkavtvrtaph
pgfptdmqaqftllnmmakgggvitetifenrfmhvpelkrmgakaeiegntvicgdvdr
lsgaqvmatdlrasaslviagciakgetivdriyhidrgyeriedklsalganierfrd

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4r7uD (D:)
snamekfrvigstqplqgevtisgaknaalpilfasilaeepvevanvphlrdidttmel
lerlgakverngsvhvdagpinqycapydlvktmrasiwalgplvarfgqgqvslpggca
igarpvdlhihgleqlgatitledgyvkahvdgrlqgahivmdkvsvgatitimcaatla
egttvldnaarepeivdtamflnklgakisgagtdsitiegverlgggkhavvpdrietg
tflvaaavsrgkivcrnthahlleavlakleeagaeiecgedwisldmtgrelkavtvrt
aphpgfptdmqaqftllnmmakgggvitetifenrfmhvpelkrmgakaeiegntvicgd
vdrlsgaqvmatdlrasaslviagciakgetivdriyhidrgyeriedklsalganierf
rd

    Sequence, based on observed residues (ATOM records): (download) 
    >4r7uD (D:)
mekfrvigstqplqgevtisgaknaalpilfasilaeepvevanvphlrdidttmeller
lgakverngsvhvdagpinqycapydlvktmrasiwalgplvarfgqgqvslpggcaiga
rpvdlhihgleqlgatitledgyvkahvdgrlqgahivmdkvsvgatitimcaatlaegt
tvldnaarepeivdtamflnklgakisgagtdsitiegverlgggkhavvpdrietgtfl
vaaavsrgkivcrnthahlleavlakleeagaeiecgedwisldmtgrelkavtvrtaph
pgfptdmqaqftllnmmakgggvitetifenrfmhvpelkrmgakaeiegntvicgdvdr
lsgaqvmatdlrasaslviagciakgetivdriyhidrgyeriedklsalganierfr