PDB entry 4r6v
View 4r6v on RCSB PDB site
Description: Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex with FIIN-3, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR kinase Gate-Keeper Mutations
Class: Transferase/transferase inhibitor
Keywords: Kinase Domain Fold, Cell Signaling, Phosphotransferase, Plasmamembrane, Transferase-transferase inhibitor complex
Deposited on
2014-08-26, released
2014-10-29
The last revision prior to the SCOPe 2.05 freeze date was dated
2014-11-26, with a file datestamp of
2014-11-21.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: 0.179
AEROSPACI score: 0.31
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Fibroblast growth factor receptor 4
Species: Homo sapiens [TaxId:9606]
Gene: FGFR4, JTK2, TKF
Database cross-references and differences (RAF-indexed):
- Uniprot P22455 (14-End)
- expression tag (12-13)
- engineered mutation (119)
- engineered mutation (233)
Domains in SCOPe 2.05: d4r6va_ - Heterogens: FI3, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4r6vA (A:)
mgsshhhhhhsqdpllaglvsldlpldplwefprdrlvlgkplgegcfgqvvraeafgmd
parpdqastvavkmlkdnasdkdladlvsemevmkligrhkniinllgvctqegplyvil
ecaakgnlreflrarrppgpdlspdgprssegplsfpvlvscayqvargmqylesrkcih
rdlaarnvlvtednvmkiadfglargvhhidyykktsngrlpvkwmapealfdevythqs
dvwsfgillweiftlggspypgipveelfsllreghrmdrpphcppelyglmrecwhaap
sqrptfkqlvealdkvllavsee
Sequence, based on observed residues (ATOM records): (download)
>4r6vA (A:)
dpllaglvsldlpldplwefprdrlvlgkplgegcfgqvvraeafgmdqastvavkmlkd
nasdkdladlvsemevmkligrhkniinllgvctqegplyvilecaakgnlreflrarrp
pgplsfpvlvscayqvargmqylesrkcihrdlaarnvlvtednvmkiadfglapvkwma
pealfdevythqsdvwsfgillweiftlggspypgipveelfsllreghrmdrpphcppe
lyglmrecwhaapsqrptfkqlvealdkvllav