PDB entry 4r3o

View 4r3o on RCSB PDB site
Description: Human Constitutive 20S Proteasome
Class: hydrolase
Keywords: Hydrolase
Deposited on 2014-08-16, released 2015-01-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-02-18, with a file datestamp of 2015-02-13.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.206
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain '1':
    Compound: Proteasome subunit beta type-1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3o1_
  • Chain '2':
    Compound: Proteasome subunit beta type-4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3o2_
  • Chain 'A':
    Compound: Proteasome subunit alpha type-6
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3oa_
  • Chain 'B':
    Compound: Proteasome subunit alpha type-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3ob_
  • Chain 'C':
    Compound: Proteasome subunit alpha type-4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3oc_
  • Chain 'D':
    Compound: Proteasome subunit alpha type-7
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Proteasome subunit alpha type-5
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3oe_
  • Chain 'F':
    Compound: Proteasome subunit alpha type-1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3of_
  • Chain 'G':
    Compound: Proteasome subunit alpha type-3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3og_
  • Chain 'H':
    Compound: Proteasome subunit beta type-6
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3oh_
  • Chain 'I':
    Compound: Proteasome subunit beta type-7
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3oi_
  • Chain 'J':
    Compound: Proteasome subunit beta type-3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3oj_
  • Chain 'K':
    Compound: Proteasome subunit beta type-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3ok_
  • Chain 'L':
    Compound: Proteasome subunit beta type-5
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3ol_
  • Chain 'M':
    Compound: Proteasome subunit beta type-1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3om_
  • Chain 'N':
    Compound: Proteasome subunit beta type-4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3on_
  • Chain 'O':
    Compound: Proteasome subunit alpha type-6
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3oo_
  • Chain 'P':
    Compound: Proteasome subunit alpha type-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3op_
  • Chain 'Q':
    Compound: Proteasome subunit alpha type-4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3oq_
  • Chain 'R':
    Compound: Proteasome subunit alpha type-7
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'S':
    Compound: Proteasome subunit alpha type-5
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3os_
  • Chain 'T':
    Compound: Proteasome subunit alpha type-1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3ot_
  • Chain 'U':
    Compound: Proteasome subunit alpha type-3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3ou_
  • Chain 'V':
    Compound: Proteasome subunit beta type-6
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3ov_
  • Chain 'W':
    Compound: Proteasome subunit beta type-7
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3ow_
  • Chain 'X':
    Compound: Proteasome subunit beta type-3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3ox_
  • Chain 'Y':
    Compound: Proteasome subunit beta type-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3oy_
  • Chain 'Z':
    Compound: Proteasome subunit beta type-5
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r3oz_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain '1':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3o1 (1:)
rfspyvfnggtilaiagedfaivasdtrlsegfsihtrdspkcykltdktvigcsgfhgd
cltltkiiearlkmykhsnnkamttgaiaamlstilysrrffpyyvyniiggldeegkga
vysfdpvgsyqrdsfkaggsasamlqplldnqvgfknmqnvehvplsldramrlvkdvfi
saaerdvytgdalricivtkegireetvslrkd

  • Chain '2':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3o2 (2:)
tqnpmvtgtsvlgvkfeggvviaadmlgsygslarfrnisrimrvnnstmlgasgdyadf
qylkqvlgqmvideellgdghsyspraihswltramysrrskmnplwntmviggyadges
flgyvdmlgvayeapslatgygaylaqpllrevlekqpvlsqteardlvercmrvlyyrd
arsynrfqiatvtekgveiegplstetnwdiahmisg

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oA (A:)
srgssagfdrhitifspegrlyqveyafkainqggltsvavrgkdcavivtqkkvpdkll
dsstvthlfkitenigcvmtgmtadsrsqvqraryeaanwkykygyeipvdmlckriadi
sqvytqnaemrplgccmiligideeqgpqvykcdpagyycgfkataagvkqtestsflek
kvkkkfdwtfeqtvetaitclstvlsidfkpseievgvvtvenpkfrilteaeidahlva
laer

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oB (B:)
aergysfslttfspsgklvqieyalaavaggapsvgikaangvvlatekkqksilyders
vhkvepitkhiglvysgmgpdyrvlvhrarklaqqyylvyqepiptaqlvqrvasvmqey
tqsggvrpfgvsllicgwnegrpylfqsdpsgayfawkatamgknyvngktflekryned
leledaihtailtlkesfegqmtednievgicneagfrrltptevkdylaaia

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oC (C:)
srrydsrttifspegrlyqveyameaighagtclgilandgvllaaerrnihklldevff
sekiyklnedmacsvagitsdanvltnelrliaqryllqyqepipceqlvtalcdikqay
tqfggkrpfgvsllyigwdkhygfqlyqsdpsgnyggwkatcignnsaaavsmlkqdyke
gemtlksalalaikvlnktmdvsklsaekveiatltrengktvirvlkqkeveqlikkhe
eeeakaerek

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oE (E:)
ydrgvntfspegrlfqveyaieaiklgstaigiqtsegvclavekritsplmepssieki
veidahigcamsgliadaktlidkarvetqnhwftynetmtvesvtqavsnlalqfgeed
adpgamsrpfgvallfggvdekgpqlfhmdpsgtfvqcdaraigsasegaqsslqevyhk
smtlkeaikssliilkqvmeeklnatnielatvqpgqnfhmftkeeleevikdi

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oF (F:)
nqydndvtvwspqgrihqieyameavkqgsatvglkskthavlvalkraqselaahqkki
lhvdnhigisiagltadarllcnfmrqecldsrfvfdrplpvsrlvsligsktqiptqry
grrpygvglliagyddmgphifqtcpsanyfdcramsigarsqsartylerhmsefmecn
lnelvkhglralretlpaeqdlttknvsigivgkdleftiyddddvspflegleerpq

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oG (G:)
ssigtgydlsastfspdgrvfqveyamkavensstaigirckdgvvfgveklvlsklyee
gsnkrlfnvdrhvgmavaglladarsladiareeasnfrsnfgyniplkhladrvamyvh
aytlysavrpfgcsfmlgsysvndgaqlymidpsgvsygywgcaigkarqaakteieklq
mkemtcrdivkevakiiyivhdevkdkafelelswvgeltngrheivpkdireeaekyak
eslke

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oH (H:)
ttimavqfdggvvlgadsrtttgsyianrvtdkltpihdrifccrsgsaadtqavadavt
yqlgfhsielnepplvhtaaslfkemcyryredlmagiiiagwdpqeggqvysvpmggmm
vrqsfaiggsgssyiygyvdatyregmtkeeclqftanalalamerdgssggvirlaaia
esgverqvllgdqipkfavatl

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oI (I:)
ttiagvvykdgivlgadtrategmvvadkncskihfispniyccgagtaadtdmttqlis
snlelhslstgrlprvvtanrmlkqmlfryqgyigaalvlggvdvtgphlysiyphgstd
klpyvtmgsgslaamavfedkfrpdmeeeeaknlvseaiaagifndlgsgsnidlcvisk
nkldflrpytvpnkkgtrlgryrcekgttavltekitple

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oJ (J:)
simsynggavmamkgkncvaiaadrrfgiqaqmvttdfqkifpmgdrlyiglaglatdvq
tvaqrlkfrlnlyelkegrqikpytlmsmvanllyekrfgpyytepviagldpktfkpfi
csldligcpmvtddfvvsgtcaeqmygmceslwepnmdpdhlfetisqamlnavdrdavs
gmgvivhiiekdkittrtlkarmd

  • Chain 'K':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oK (K:)
meyligiqgpdyvlvasdrvaasnivqmkddhdkmfkmsekilllcvgeagdtvqfaeyi
qknvqlykmrngyelsptaaanftrrnladclrsrtpyhvnlllagydehegpalyymdy
laalakapfaahgygafltlsildryytptisreravellrkcleelqkrfilnlptfsv
riidkngihdldnisfpkq

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oL (L:)
tttlafkfrhgvivaadsratagayiasqtvkkvieinpyllgtmaggaadcsfwerlla
rqcriyelrnkerisvaaaskllanmvyqykgmglsmgtmicgwdkrgpglyyvdsegnr
isgatfsvgsgsvyaygvmdrgysydleveqaydlarraiyqatyrdaysggavnlyhvr
edgwirvssdnvadlhekysg

  • Chain 'M':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oM (M:)
rfspyvfnggtilaiagedfaivasdtrlsegfsihtrdspkcykltdktvigcsgfhgd
cltltkiiearlkmykhsnnkamttgaiaamlstilysrrffpyyvyniiggldeegkga
vysfdpvgsyqrdsfkaggsasamlqplldnqvgfknmqnvehvplsldramrlvkdvfi
saaerdvytgdalricivtkegireetvslrkd

  • Chain 'N':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oN (N:)
tqnpmvtgtsvlgvkfeggvviaadmlgsygslarfrnisrimrvnnstmlgasgdyadf
qylkqvlgqmvideellgdghsyspraihswltramysrrskmnplwntmviggyadges
flgyvdmlgvayeapslatgygaylaqpllrevlekqpvlsqteardlvercmrvlyyrd
arsynrfqiatvtekgveiegplstetnwdiahmisg

  • Chain 'O':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oO (O:)
srgssagfdrhitifspegrlyqveyafkainqggltsvavrgkdcavivtqkkvpdkll
dsstvthlfkitenigcvmtgmtadsrsqvqraryeaanwkykygyeipvdmlckriadi
sqvytqnaemrplgccmiligideeqgpqvykcdpagyycgfkataagvkqtestsflek
kvkkkfdwtfeqtvetaitclstvlsidfkpseievgvvtvenpkfrilteaeidahlva
laer

  • Chain 'P':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oP (P:)
aergysfslttfspsgklvqieyalaavaggapsvgikaangvvlatekkqksilyders
vhkvepitkhiglvysgmgpdyrvlvhrarklaqqyylvyqepiptaqlvqrvasvmqey
tqsggvrpfgvsllicgwnegrpylfqsdpsgayfawkatamgknyvngktflekryned
leledaihtailtlkesfegqmtednievgicneagfrrltptevkdylaaia

  • Chain 'Q':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oQ (Q:)
srrydsrttifspegrlyqveyameaighagtclgilandgvllaaerrnihklldevff
sekiyklnedmacsvagitsdanvltnelrliaqryllqyqepipceqlvtalcdikqay
tqfggkrpfgvsllyigwdkhygfqlyqsdpsgnyggwkatcignnsaaavsmlkqdyke
gemtlksalalaikvlnktmdvsklsaekveiatltrengktvirvlkqkeveqlikkhe
eeeakaerek

  • Chain 'R':
    No sequence available.

  • Chain 'S':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oS (S:)
ydrgvntfspegrlfqveyaieaiklgstaigiqtsegvclavekritsplmepssieki
veidahigcamsgliadaktlidkarvetqnhwftynetmtvesvtqavsnlalqfgeed
adpgamsrpfgvallfggvdekgpqlfhmdpsgtfvqcdaraigsasegaqsslqevyhk
smtlkeaikssliilkqvmeeklnatnielatvqpgqnfhmftkeeleevikdi

  • Chain 'T':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oT (T:)
nqydndvtvwspqgrihqieyameavkqgsatvglkskthavlvalkraqselaahqkki
lhvdnhigisiagltadarllcnfmrqecldsrfvfdrplpvsrlvsligsktqiptqry
grrpygvglliagyddmgphifqtcpsanyfdcramsigarsqsartylerhmsefmecn
lnelvkhglralretlpaeqdlttknvsigivgkdleftiyddddvspflegleerpq

  • Chain 'U':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oU (U:)
ssigtgydlsastfspdgrvfqveyamkavensstaigirckdgvvfgveklvlsklyee
gsnkrlfnvdrhvgmavaglladarsladiareeasnfrsnfgyniplkhladrvamyvh
aytlysavrpfgcsfmlgsysvndgaqlymidpsgvsygywgcaigkarqaakteieklq
mkemtcrdivkevakiiyivhdevkdkafelelswvgeltngrheivpkdireeaekyak
eslke

  • Chain 'V':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oV (V:)
ttimavqfdggvvlgadsrtttgsyianrvtdkltpihdrifccrsgsaadtqavadavt
yqlgfhsielnepplvhtaaslfkemcyryredlmagiiiagwdpqeggqvysvpmggmm
vrqsfaiggsgssyiygyvdatyregmtkeeclqftanalalamerdgssggvirlaaia
esgverqvllgdqipkfavatl

  • Chain 'W':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oW (W:)
ttiagvvykdgivlgadtrategmvvadkncskihfispniyccgagtaadtdmttqlis
snlelhslstgrlprvvtanrmlkqmlfryqgyigaalvlggvdvtgphlysiyphgstd
klpyvtmgsgslaamavfedkfrpdmeeeeaknlvseaiaagifndlgsgsnidlcvisk
nkldflrpytvpnkkgtrlgryrcekgttavltekitple

  • Chain 'X':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oX (X:)
simsynggavmamkgkncvaiaadrrfgiqaqmvttdfqkifpmgdrlyiglaglatdvq
tvaqrlkfrlnlyelkegrqikpytlmsmvanllyekrfgpyytepviagldpktfkpfi
csldligcpmvtddfvvsgtcaeqmygmceslwepnmdpdhlfetisqamlnavdrdavs
gmgvivhiiekdkittrtlkarmd

  • Chain 'Y':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oY (Y:)
meyligiqgpdyvlvasdrvaasnivqmkddhdkmfkmsekilllcvgeagdtvqfaeyi
qknvqlykmrngyelsptaaanftrrnladclrsrtpyhvnlllagydehegpalyymdy
laalakapfaahgygafltlsildryytptisreravellrkcleelqkrfilnlptfsv
riidkngihdldnisfpkq

  • Chain 'Z':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4r3oZ (Z:)
tttlafkfrhgvivaadsratagayiasqtvkkvieinpyllgtmaggaadcsfwerlla
rqcriyelrnkerisvaaaskllanmvyqykgmglsmgtmicgwdkrgpglyyvdsegnr
isgatfsvgsgsvyaygvmdrgysydleveqaydlarraiyqatyrdaysggavnlyhvr
edgwirvssdnvadlhekysg