PDB entry 4r1f

View 4r1f on RCSB PDB site
Description: Re-refined Human DNA topoisomerase IIa (ATPase and transducer domains) in complex with ADP and SO4
Class: isomerase
Keywords: Human topoisomerase IIA, ISOMERASE
Deposited on 2014-08-05, released 2014-09-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-11-05, with a file datestamp of 2014-10-31.
Experiment type: XRAY
Resolution: 2.51 Å
R-factor: 0.211
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA topoisomerase 2-alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: TOP2, TOP2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r1fa1, d4r1fa2
  • Chain 'B':
    Compound: DNA topoisomerase 2-alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: TOP2, TOP2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r1fb1, d4r1fb2
  • Chain 'C':
    Compound: DNA topoisomerase 2-alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: TOP2, TOP2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r1fc1, d4r1fc2
  • Chain 'D':
    Compound: DNA topoisomerase 2-alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: TOP2, TOP2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4r1fd1, d4r1fd2
  • Heterogens: MG, ADP, GOL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4r1fA (A:)
sveriyqkktqlehillrpdtyigsvelvtqqmwvydedvginyrevtfvpglykifdei
lvnaadnkqrdpkmscirvtidpennlisiwnngkgipvvehkvekmyvpalifgqllts
snydddekkvtggrngygaklcnifstkftvetasreykkmfkqtwmdnmgragemelkp
fngedytcitfqpdlskfkmqsldkdivalmvrraydiagstkdvkvflngnklpvkgfr
syvdmylkdkldetgnslkviheqvnhrwevcltmsekgfqqisfvnsiatskggrhvdy
vadqivtklvdvvkkknkggvavkahqvknhmwifvnalienptfdsqtkenmtlqpksf
gstcqlsekfikaaigcgivesilnwvkfkaqvqlnkkcs

    Sequence, based on observed residues (ATOM records): (download) 
    >4r1fA (A:)
sveriyqkktqlehillrpdtyigsvelvtqqmwvydedvginyrevtfvpglykifdei
lvnaadnkqrdpkmscirvtidpennlisiwnngkgipvvehkvekmyvpalifgqllts
snydddekkvtggrngygaklcnifstkftvetasreykkmfkqtwmdnmgragemelkp
fngedytcitfqpdlskfkmqsldkdivalmvrraydiagstkdvkvflngnklpvkgfr
syvdmylkviheqvnhrwevcltmsekgfqqisfvnsiatskggrhvdyvadqivtklvh
qvknhmwifvnalienptfdsqtkenmtlqpksfgstcqlsekfikaaigivesilnwvk
fkaqvq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4r1fB (B:)
sveriyqkktqlehillrpdtyigsvelvtqqmwvydedvginyrevtfvpglykifdei
lvnaadnkqrdpkmscirvtidpennlisiwnngkgipvvehkvekmyvpalifgqllts
snydddekkvtggrngygaklcnifstkftvetasreykkmfkqtwmdnmgragemelkp
fngedytcitfqpdlskfkmqsldkdivalmvrraydiagstkdvkvflngnklpvkgfr
syvdmylkdkldetgnslkviheqvnhrwevcltmsekgfqqisfvnsiatskggrhvdy
vadqivtklvdvvkkknkggvavkahqvknhmwifvnalienptfdsqtkenmtlqpksf
gstcqlsekfikaaigcgivesilnwvkfkaqvqlnkkcs

    Sequence, based on observed residues (ATOM records): (download) 
    >4r1fB (B:)
sveriyqkktqlehillrpdtyigsvelvtqqmwvydedvginyrevtfvpglykifdei
lvnaadnkqrdpkmscirvtidpennlisiwnngkgipvvehkvekmyvpalifgqllts
snydddekkvtggrngygaklcnifstkftvetasreykkmfkqtwmdnmgragemelkp
fngedytcitfqpdlskfkmqsldkdivalmvrraydiagstkdvkvflngnklpvkgfr
syvdmylkkviheqvnhrwevcltmsekgfqqisfvnsiatskggrhvdyvadqivtklv
dvvkkkkahqvknhmwifvnalienptfdsqtkenmtlqpksfgstcqlsekfikaaigc
givesilnwvkfkaqvqln

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4r1fC (C:)
sveriyqkktqlehillrpdtyigsvelvtqqmwvydedvginyrevtfvpglykifdei
lvnaadnkqrdpkmscirvtidpennlisiwnngkgipvvehkvekmyvpalifgqllts
snydddekkvtggrngygaklcnifstkftvetasreykkmfkqtwmdnmgragemelkp
fngedytcitfqpdlskfkmqsldkdivalmvrraydiagstkdvkvflngnklpvkgfr
syvdmylkdkldetgnslkviheqvnhrwevcltmsekgfqqisfvnsiatskggrhvdy
vadqivtklvdvvkkknkggvavkahqvknhmwifvnalienptfdsqtkenmtlqpksf
gstcqlsekfikaaigcgivesilnwvkfkaqvqlnkkcs

    Sequence, based on observed residues (ATOM records): (download) 
    >4r1fC (C:)
sveriyqkktqlehillrpdtyigsvelvtqqmwvydedvginyrevtfvpglykifdei
lvnaadnkqrdpkmscirvtidpennlisiwnngkgipvvehkvekmyvpalifgqllts
snyddkvtggrngygaklcnifstkftvetasreykkmfkqtwmdnmgragemelkpfng
edytcitfqpdlskfkmqsldkdivalmvrraydiagstkdvkvflngnklpvkgfrsyv
dmylkviheqvnhrwevcltmsekgfqqisfvnsiatskggrhvdyvadqivtklvdvvk
kknkggvavkahqvknhmwifvnalienptfdsqtkenmtlqpksfgstcqlsekfikaa
igcgivesilnwvkfkaqvqlnkk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4r1fD (D:)
sveriyqkktqlehillrpdtyigsvelvtqqmwvydedvginyrevtfvpglykifdei
lvnaadnkqrdpkmscirvtidpennlisiwnngkgipvvehkvekmyvpalifgqllts
snydddekkvtggrngygaklcnifstkftvetasreykkmfkqtwmdnmgragemelkp
fngedytcitfqpdlskfkmqsldkdivalmvrraydiagstkdvkvflngnklpvkgfr
syvdmylkdkldetgnslkviheqvnhrwevcltmsekgfqqisfvnsiatskggrhvdy
vadqivtklvdvvkkknkggvavkahqvknhmwifvnalienptfdsqtkenmtlqpksf
gstcqlsekfikaaigcgivesilnwvkfkaqvqlnkkcs

    Sequence, based on observed residues (ATOM records): (download) 
    >4r1fD (D:)
sveriyqkktqlehillrpdtyigsvelvtqqmwvydedvginyrevtfvpglykifdei
lvnaadnkqrdpkmscirvtidpennlisiwnngkgipvvehkvekmyvpalifgqllts
snydddekkvtggrngygaklcnifstkftvetasreykkmfkqtwmdnmgragemelkp
fngedytcitfqpdlskfkmqsldkdivalmvrraydiagstkdvkvflngnklpvkgfr
syvdmylkkviheqvnhrwevcltmsekgfqqisfvnsiatskggrhvdyvadqivtklv
dvvkkahqvknhmwifvnalienptfdsqtkenmtlqpksfgstcqlsekfikaaigcgi
vwvkfkaqvqlnk