PDB entry 4qun

View 4qun on RCSB PDB site
Description: Crystal structure of the PTPN3 (PTPH1) catalytic domain C842S mutant
Class: Hydrolase
Keywords: Alpha Beta, Hydrolase
Deposited on 2014-07-11, released 2014-12-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-12-10, with a file datestamp of 2014-12-05.
Experiment type: XRAY
Resolution: 1.86 Å
R-factor: 0.178
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 3
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPH1, PTPN3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26045 (24-End)
      • expression tag (22-23)
      • engineered mutation (238)
    Domains in SCOPe 2.08: d4quna1, d4quna2
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 3
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPH1, PTPN3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26045 (24-End)
      • expression tag (22-23)
      • engineered mutation (238)
    Domains in SCOPe 2.08: d4qunb1, d4qunb2
  • Heterogens: PO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4qunA (A:)
    mhhhhhhssgvdlgtenlyfqsnadtlegsmaqlkkglesgtvliqfeqlyrkkpglait
    faklpqnldknrykdvlpydttrvllqgnedyinasyvnmeipaanlvnkyiatqgplph
    tcaqfwqvvwdqklslivmlttltergrtkchqywpdppdvmnhggfhiqcqsedctiay
    vsremlvtntqtgeehtvthlqyvawpdhgvpddssdflefvnyvrslrvdsepvlvhss
    agigrtgvlvtmetamclternlpiypldivrkmrdqrammvqtssqykfvceailrvye
    eglvqm
    

    Sequence, based on observed residues (ATOM records): (download)
    >4qunA (A:)
    nadtlegsmaqlkkglesgtvliqfeqlyrkkpglaitfaklpqnldknrykdvlpydtt
    rvllqgnedyinasyvnmeipaanlvnkyiatqgplphtcaqfwqvvwdqklslivmltt
    ltergrtkchqywpdppdvmnhggfhiqcqsedctiayvsremlvtntqtgeehtvthlq
    yvawpdhgvpddssdflefvnyvrslrvdsepvlvhssagigrtgvlvtmetamcltern
    lpiypldivrkmrdqrammvqtssqykfvceailrvyeeglvq
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4qunB (B:)
    mhhhhhhssgvdlgtenlyfqsnadtlegsmaqlkkglesgtvliqfeqlyrkkpglait
    faklpqnldknrykdvlpydttrvllqgnedyinasyvnmeipaanlvnkyiatqgplph
    tcaqfwqvvwdqklslivmlttltergrtkchqywpdppdvmnhggfhiqcqsedctiay
    vsremlvtntqtgeehtvthlqyvawpdhgvpddssdflefvnyvrslrvdsepvlvhss
    agigrtgvlvtmetamclternlpiypldivrkmrdqrammvqtssqykfvceailrvye
    eglvqm
    

    Sequence, based on observed residues (ATOM records): (download)
    >4qunB (B:)
    nadtlegsmaqlkkglesgtvliqfeqlyrkkpglaitfaklpqnldknrykdvlpydtt
    rvllqgnedyinasyvnmeipaanlvnkyiatqgplphtcaqfwqvvwdqklslivmltt
    ltergrtkchqywpdppdvmnhggfhiqcqsedctiayvsremlvtntqtgeehtvthlq
    yvawpdhgvpddssdflefvnyvrslrvdsepvlvhssagigrtgvlvtmetamcltern
    lpiypldivrkmrdqrammvqtssqykfvceailrvyeeglvq