PDB entry 4qun
View 4qun on RCSB PDB site
Description: Crystal structure of the PTPN3 (PTPH1) catalytic domain C842S mutant
Class: Hydrolase
Keywords: Alpha Beta, Hydrolase
Deposited on
2014-07-11, released
2014-12-10
The last revision prior to the SCOPe 2.08 freeze date was dated
2014-12-10, with a file datestamp of
2014-12-05.
Experiment type: XRAY
Resolution: 1.86 Å
R-factor: 0.178
AEROSPACI score: 0.43
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Tyrosine-protein phosphatase non-receptor type 3
Species: Homo sapiens [TaxId:9606]
Gene: PTPH1, PTPN3
Database cross-references and differences (RAF-indexed):
- Uniprot P26045 (24-End)
- expression tag (22-23)
- engineered mutation (238)
Domains in SCOPe 2.08: d4quna1, d4quna2 - Chain 'B':
Compound: Tyrosine-protein phosphatase non-receptor type 3
Species: Homo sapiens [TaxId:9606]
Gene: PTPH1, PTPN3
Database cross-references and differences (RAF-indexed):
- Uniprot P26045 (24-End)
- expression tag (22-23)
- engineered mutation (238)
Domains in SCOPe 2.08: d4qunb1, d4qunb2 - Heterogens: PO4, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4qunA (A:)
mhhhhhhssgvdlgtenlyfqsnadtlegsmaqlkkglesgtvliqfeqlyrkkpglait
faklpqnldknrykdvlpydttrvllqgnedyinasyvnmeipaanlvnkyiatqgplph
tcaqfwqvvwdqklslivmlttltergrtkchqywpdppdvmnhggfhiqcqsedctiay
vsremlvtntqtgeehtvthlqyvawpdhgvpddssdflefvnyvrslrvdsepvlvhss
agigrtgvlvtmetamclternlpiypldivrkmrdqrammvqtssqykfvceailrvye
eglvqm
Sequence, based on observed residues (ATOM records): (download)
>4qunA (A:)
nadtlegsmaqlkkglesgtvliqfeqlyrkkpglaitfaklpqnldknrykdvlpydtt
rvllqgnedyinasyvnmeipaanlvnkyiatqgplphtcaqfwqvvwdqklslivmltt
ltergrtkchqywpdppdvmnhggfhiqcqsedctiayvsremlvtntqtgeehtvthlq
yvawpdhgvpddssdflefvnyvrslrvdsepvlvhssagigrtgvlvtmetamcltern
lpiypldivrkmrdqrammvqtssqykfvceailrvyeeglvq
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4qunB (B:)
mhhhhhhssgvdlgtenlyfqsnadtlegsmaqlkkglesgtvliqfeqlyrkkpglait
faklpqnldknrykdvlpydttrvllqgnedyinasyvnmeipaanlvnkyiatqgplph
tcaqfwqvvwdqklslivmlttltergrtkchqywpdppdvmnhggfhiqcqsedctiay
vsremlvtntqtgeehtvthlqyvawpdhgvpddssdflefvnyvrslrvdsepvlvhss
agigrtgvlvtmetamclternlpiypldivrkmrdqrammvqtssqykfvceailrvye
eglvqm
Sequence, based on observed residues (ATOM records): (download)
>4qunB (B:)
nadtlegsmaqlkkglesgtvliqfeqlyrkkpglaitfaklpqnldknrykdvlpydtt
rvllqgnedyinasyvnmeipaanlvnkyiatqgplphtcaqfwqvvwdqklslivmltt
ltergrtkchqywpdppdvmnhggfhiqcqsedctiayvsremlvtntqtgeehtvthlq
yvawpdhgvpddssdflefvnyvrslrvdsepvlvhssagigrtgvlvtmetamcltern
lpiypldivrkmrdqrammvqtssqykfvceailrvyeeglvq