PDB entry 4qti

View 4qti on RCSB PDB site
Description: Crystal structure of human uPAR in complex with anti-uPAR Fab 8B12
Class: immune system
Keywords: allosteric regulation, cell surface, IMMUNE SYSTEM
Deposited on 2014-07-08, released 2015-02-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-02-25, with a file datestamp of 2015-02-20.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.252
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: anti-uPAR antibody, heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 4QTI (0-End)
    Domains in SCOPe 2.08: d4qtih1, d4qtih2
  • Chain 'L':
    Compound: anti-uPAR antibody, light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 4QTI (0-End)
    Domains in SCOPe 2.08: d4qtil1, d4qtil2
  • Chain 'U':
    Compound: Urokinase plasminogen activator surface receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: PLAUR, MO3, UPAR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4qtiu1, d4qtiu2, d4qtiu3

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4qtiH (H:)
qvqlqqsgaelmkpgasvklsckaagytftaywiewirqrpghglewigeilpgssstnc
nemfkgkatftadtssnsaymqlsslttedsaiyyctrdfsgdrsnlyfdvwgtgttvtv
ssakttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlq
sdlytlsssvtvpsstwpsetvtcnvahpasstkvdkkivprdc

    Sequence, based on observed residues (ATOM records): (download) 
    >4qtiH (H:)
qvqlqqsgaelmkpgasvklsckaagytftaywiewirqrpghglewigeilpgssstnc
nemfkgkatftadtssnsaymqlsslttedsaiyyctrdfsgdrsnlyfdvwgtgttvtv
ssakttppsvyplaptnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlyt
lsssvtvpsstwpsetvtcnvahpasstkvdkkivprd

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >4qtiL (L:)
diqmtqspsslsaslgervsltcrasqdigsslnwlqqepdgtikrliyatssldsgvpk
rfsgsrsgsdysltisrlesedfvdyyclqyatspytfgggtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >4qtiL (L:)
diqmtqspsslsaslgervsltcrasqdigsslnwlqqepdgtikrliyatssldsgvpk
rfsgsrsgsdysltisrlesedfvdyyclqyatspytfgggtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrn

  • Chain 'U':
    Sequence, based on SEQRES records: (download) 
    >4qtiU (U:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqgnsgravtysrsryleciscgssdmscergrhqslqcrspee
qcldvvthwiqegeegrpkddrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegp
ilelenlpqngrqcysckgnsthgcsseetflidcrgpmnqclvatgthepknqsymvrg
catasmcqhahlgdafsmnhidvscctksgcnhpdldvqyrsg

    Sequence, based on observed residues (ATOM records): (download) 
    >4qtiU (U:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqgnsrsryleciscgssdmscergrhqslqcrspeeqcldvvt
hwidrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegpilelenlpqngrqcysc
kgnsthgcsseetflidcrgpmnqclvatgthepknqsymvrgcatasmcqhahlgdafs
mnhidvscctksgcnhpdld