PDB entry 4qtd

View 4qtd on RCSB PDB site
Description: Structure of human JNK1 in complex with SCH772984 and the AMPPNP-hydrolysed triphosphate revealing the second type-I binding mode
Class: Transferase/transferase inhibitor
Keywords: Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE, kinase, MAPK, signalling, inhibitor, allosteric, Structural Genomics Consortium (SGC), Transferase-transferase inhibitor complex
Deposited on 2014-07-07, released 2014-07-23
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-07-23, with a file datestamp of 2014-07-18.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: 0.167
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 8
    Species: Homo sapiens [TaxId:9606]
    Gene: JNK1, MAPK8, PRKM8, SAPK1, SAPK1C
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4qtda_
  • Heterogens: EDO, EPE, 38Z, ANP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4qtdA (A:)
    smsrskrdnnfysveigdstftvlkryqnlkpigsgaqgivcaaydailernvaikklsr
    pfqnqthakrayrelvlmkcvnhkniigllnvftpqksleefqdvyivmelmdanlcqvi
    qmeldhermsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagts
    fmmtpyvvtryyrapevilgmgykenvdlwsvgcimgemvchkilfpgrdyidqwnkvie
    qlgtpcpefmkklqptvrtyvenrpkyagysfeklfpdvlfpadsehnklkasqardlls
    kmlvidaskrisvdealqhpyinvwydpseaeapppkipdkqlderehtieewkeliyke
    vmdl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4qtdA (A:)
    rdnnfysveigdstftvlkryqnlkpigsgaqgivcaaydailernvaikklsrpfqnqt
    hakrayrelvlmkcvnhkniigllnvftpqksleefqdvyivmelmdanlcqviqmeldh
    ermsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartsfmmtpyvvt
    ryyrapevilgmgykenvdlwsvgcimgemvchkilfpgrdyidqwnkvieqlgtpcpef
    mkklqptvrtyvenrpkyagysfeklfpdvlfpadsehnklkasqardllskmlvidask
    risvdealqhpyinvwydpseaeapppkipdkqlderehtieewkeliykevmdl