PDB entry 4qta

View 4qta on RCSB PDB site
Description: Structure of human ERK2 in complex with SCH772984 revealing a novel inhibitor-induced binding pocket
Class: Transferase/transferase inhibitor
Keywords: Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE, kinase, MAPK, signalling, inhibitor, allosteric, Structural Genomics Consortium (SGC), Transferase-transferase inhibitor complex
Deposited on 2014-07-07, released 2014-07-23
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-07-23, with a file datestamp of 2014-07-18.
Experiment type: XRAY
Resolution: 1.45 Å
R-factor: 0.16
AEROSPACI score: 0.6 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: ERK2, MAPK1, PRKM1, PRKM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4qtaa_
  • Heterogens: EDO, SO4, 38Z, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4qtaA (A:)
    smaaaaaagagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispf
    ehqtycqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktq
    hlsndhicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhd
    htgflteyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnh
    ilgilgspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnph
    krieveqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgyr
    s
    

    Sequence, based on observed residues (ATOM records): (download)
    >4qtaA (A:)
    gpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtl
    reikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyf
    lyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadtrwyrapeimlnsk
    gytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciinlkarny
    llslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyydpsdep
    iaeapfkfdmelddlpkeklkelifeetarfqpgy