PDB entry 4qps

View 4qps on RCSB PDB site
Description: Crystal structure of Jak3 complexed to N-[3-(6-Phenylamino-pyrazin-2-yl)-3H-benzoimidazol-5-yl]-acrylamide
Class: Transferase/transferase inhibitor
Keywords: Kinase catalytic domain, TRANSFERASE, Transferase-transferase inhibitor complex
Deposited on 2014-06-24, released 2015-01-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-03-11, with a file datestamp of 2015-03-06.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK3
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52333
      • engineered mutation (138)
      • engineered mutation (229)
      • engineered mutation (237)
    Domains in SCOPe 2.08: d4qpsa_
  • Chain 'C':
    Compound: Tyrosine-protein kinase JAK3
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52333
      • engineered mutation (138)
      • engineered mutation (229)
      • engineered mutation (237)
    Domains in SCOPe 2.08: d4qpsc_
  • Heterogens: 37Q, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4qpsA (A:)
cqdptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqr
eiqilkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllys
sqickgmeylgsrrcvhralaarnilveseahvkiadfglakllpldkdyyvvrepgqsp
ifwyapeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsrl
lelleegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlwsgsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4qpsA (A:)
ptifeerhlkyisqlgkgngsvelcrydplgdntgalvavkqldqqrdfqreiqilkalh
sdfivkyrgvsyslrlvmeylpsgclrdflqrhrarldasrlllyssqickgmeylgsrr
cvhralaarnilveseahvkiadfglakllpldkdyyvvpifwyapeslsdnifsrqsdv
wsfgvvlyelftycdkscspsaeflrmmgserdvpalsrllelleegqrlpappacpaev
helmklcwapspqdrpsfsalgpqldmlws

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4qpsC (C:)
cqdptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqr
eiqilkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllys
sqickgmeylgsrrcvhralaarnilveseahvkiadfglakllpldkdyyvvrepgqsp
ifwyapeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsrl
lelleegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlwsgsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4qpsC (C:)
ptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlsgpdqqrdfqreiqil
kalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllyssqick
gmeylgsrrcvhralaarnilveseahvkiadfglakllpldkdyyvvspifwyapesls
dnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgslsrllelleegqrlpappac
paevhelmklcwapspqdrpsfsalgpqldmlwsgs