PDB entry 4qp7

View 4qp7 on RCSB PDB site
Description: Crystal Structure of ERK2 in complex with 2-(1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine
Class: transferase/transferase inhibitor
Keywords: Kinase, transferase-transferase inhibitor complex
Deposited on 2014-06-22, released 2015-09-23
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-12-16, with a file datestamp of 2015-12-11.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK1, ERK2, PRKM1, PRKM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4qp7a_
  • Chain 'B':
    Compound: Mitogen-activated protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK1, ERK2, PRKM1, PRKM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4qp7b_
  • Heterogens: 363, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4qp7A (A:)
mgshhhhhhmaaaaaagagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrv
aikkispfehqtycqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetd
lykllktqhlsndhicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfgla
rvadpdhdhtgflteyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgk
hyldqlnhilgilgspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlld
kmltfnphkrieveqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeet
arfqpgyrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4qp7A (A:)
mvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlrei
killrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyq
ilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadlteyvatrwyrapeiml
nskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciinlka
rnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyydps
depiaeapfkfdmelddlpkeklkelifeetarfqpg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4qp7B (B:)
mgshhhhhhmaaaaaagagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrv
aikkispfehqtycqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetd
lykllktqhlsndhicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfgla
rvadpdhdhtgflteyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgk
hyldqlnhilgilgspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlld
kmltfnphkrieveqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeet
arfqpgyrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4qp7B (B:)
emvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlre
ikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfly
qilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvaeyvatrwyrapeimlns
kgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciinlkarn
yllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyydpsde
piaeapfkfdmelddlpkeklkelifeetarfqpg