PDB entry 4qp3

View 4qp3 on RCSB PDB site
Description: Crystal Structure of ERK2 in complex with (S)-2-((9H-purin-6-yl)amino)-3-phenylpropan-1-ol
Class: transferase/transferase inhibitor
Keywords: Kinase, transferase-transferase inhibitor complex
Deposited on 2014-06-22, released 2015-09-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-12-16, with a file datestamp of 2015-12-11.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK1, ERK2, PRKM1, PRKM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4qp3a_
  • Chain 'B':
    Compound: Mitogen-activated protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK1, ERK2, PRKM1, PRKM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4qp3b_
  • Heterogens: 36Q, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4qp3A (A:)
mgshhhhhhmaaaaaagagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrv
aikkispfehqtycqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetd
lykllktqhlsndhicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfgla
rvadpdhdhtgflteyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgk
hyldqlnhilgilgspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlld
kmltfnphkrieveqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeet
arfqpgyrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4qp3A (A:)
emvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlre
ikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfly
qilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhyvatrwyrape
imlnytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciinlka
rnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyydps
depiaeapfkfdmelddlpkeklkelifeetarfqpgyrs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4qp3B (B:)
mgshhhhhhmaaaaaagagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrv
aikkispfehqtycqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetd
lykllktqhlsndhicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfgla
rvadpdhdhtgflteyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgk
hyldqlnhilgilgspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlld
kmltfnphkrieveqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeet
arfqpgyrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4qp3B (B:)
egqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlreiki
llrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyqil
rglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhlteyvatrwyrape
imlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspinlkarnyll
slphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyydpsdepia
eapfkfdmelddlpkeklkelifeetarfqpg