PDB entry 4qhp

View 4qhp on RCSB PDB site
Description: Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe(4-CH2NH2)
Class: hydrolase/hydrolase inhibitor
Keywords: Zn-dependent, APN, (S)-2-[4-(aminomethyl)benzyl]-3-[(R)-1-amino-3-phenylpropyl(hydroxy)phosphoryl]propanoic acid, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2014-05-28, released 2014-09-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-10-22, with a file datestamp of 2014-10-17.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.155
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aminopeptidase N
    Species: Neisseria meningitidis [TaxId:487]
    Gene: pepN, NMB1416
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4qhpa1, d4qhpa2, d4qhpa3, d4qhpa4
  • Heterogens: 32Q, 32R, IMD, GOL, ZN, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4qhpA (A:)
snamsktvhylkdyqtpayhilktdlhfdinepqtvvksrltvepqrvgeplvldgsakl
lsvkingaaadyvlegetltiagvpserftveveteilpaenkslmglyasggnlftqce
pegfrkitfyidrpdvmskftttivadkkrypvllsngnkidggefsdgrhwvkwedpfs
kpsylfalvagdlavtedyfttmsgrnvkiefytteadkpkvgfaveslknamkwdetrf
gleydldifmvvavgdfnmgamenkglnifntkfvladsrtatdtdfegiesvvgheyfh
nwtgnrvtcrdwfqlslkegltvfrdqefsgdrasravrrienirllrqhqfpedagpta
hpvrpasyeemnnfytmtvyekgaevvrmyhtllgeegfqkgmklyfqrhdgqavtcddf
raamadanginldqfalwysqagtpvleaegrlknnifeltvkqtvpptpdmtdkqpmmi
pvkvgllnrngeavafdyqgkrateavlllteaeqtfllegvteavvpsllrgfsapvhl
nypysdddlllllahdsdaftrweaaqtlyrravaanlatlsdgvelpkhekllaavekv
isddlldnafkalllgvpseaelwdgaenidplryhqarealldtlavhflpkwhelnrq
aakqenqsyeyspeaagwrtlrnvcrafvlradpahietvaekygemaqnmthewgilsa
vngnesdtrnrllaqfadkfsddalvmdkyfalvgssrrsdtlqqvrtalqhpkfslenp
nkarsligsfsrnvphfhaedgsgyrfiadkvieidrfnpqvaarlvqafnlcnklephr
knlvkqalqriraqeglskdvgeivgkild

    Sequence, based on observed residues (ATOM records): (download) 
    >4qhpA (A:)
sktvhylkdyqtpayhilktdlhfdinepqtvvksrltvepqrvgeplvldgsakllsvk
ingaaadyvlegetltiagvpserftveveteilpaenkslmglyasggnlftqcepegf
rkitfyidrpdvmskftttivadkkrypvllsngnkidggefsdgrhwvkwedpfskpsy
lfalvagdlavtedyfttmsgrnvkiefytteadkpkvgfaveslknamkwdetrfgley
dldifmvvavgdfnmgamenkglnifntkfvladsrtatdtdfegiesvvgheyfhnwtg
nrvtcrdwfqlslkegltvfrdqefsgdrasravrrienirllrqhqfpedagptahpvr
pasyeemnnfytmtvyekgaevvrmyhtllgeegfqkgmklyfqrhdgqavtcddfraam
adanginldqfalwysqagtpvleaegrlknnifeltvkqtvpptpdmtdkqpmmipvkv
gllnrngeavafdyqgkrateavlllteaeqtfllegvteavvpsllrgfsapvhlnypy
sdddlllllahdsdaftrweaaqtlyrravaanlatlsdgvelpkhekllaavekvisdd
lldnafkalllgvpseaelwdgaenidplryhqarealldtlavhflpkwhelnrqaakq
enqsyeyspeaagwrtlrnvcrafvlradpahietvaekygemaqnmthewgilsavngn
esdtrnrllaqfadkfsddalvmdkyfalvgssrrsdtlqqvrtalqhpkfslenpnkar
sligsfsrnvphfhaedgsgyrfiadkvieidrfnpqvaarlvqafnlcnklephrknlv
kqalqriraqeglskdvgeivgkild