PDB entry 4qhe

View 4qhe on RCSB PDB site
Description: Crystal structure of Mg2+ bound human APE1
Class: lyase
Keywords: Beta sandwich, Endonuclease, DNA-binding, Nucleus, LYASE
Deposited on 2014-05-28, released 2014-11-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: N/A
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA-(apurinic or apyrimidinic site) lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: APEX1, APE, APE1, APEX, APX, HAP1, REF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27695 (4-284)
      • variant (5)
      • engineered mutation (104)
    Domains in SCOPe 2.08: d4qhea_
  • Heterogens: MG, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4qheA (A:)
gshmasegpalyedppdqktspsgkpatlkicswnvdglrawikkkgldwvkeeapdilc
lqetkcsenklpaelqelpglshqywsapsdkegysgvgllsrqaplkvsygigdeehdq
egrvivaefdsfvlvtayvpnagrglvrleyrqrwdeafrkflkglasrkplvlcgdlnv
aheeidlrnpkgnkknagftpqerqgfgellqavpladsfrhlypntpyaytfwtymmna
rsknvgwrldyfllshsllpalcdskirskalgsdhcpitlylal

    Sequence, based on observed residues (ATOM records): (download) 
    >4qheA (A:)
asegpalyedppdqktspsgkpatlkicswnvdglrawikkkgldwvkeeapdilclqet
kcsenklpaelqelpglshqywsapsdkegysgvgllsrqaplkvsygigdeehdqegrv
ivaefdsfvlvtayvpnagrglvrleyrqrwdeafrkflkglasrkplvlcgdlnvahee
idlrnpkgnkknagftpqerqgfgellqavpladsfrhlypntpyaytfwtymmnarskn
vgwrldyfllshsllpalcdskirskalgsdhcpitlylal