PDB entry 4qh9

View 4qh9 on RCSB PDB site
Description: Crystal structure of Mn2+ bound human APE1
Class: lyase
Keywords: Beta Sandwich, Endonuclease, DNA-binding, Nucleus, LYASE
Deposited on 2014-05-27, released 2014-11-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.18 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA-(apurinic or apyrimidinic site) lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: APEX1, APE, APE1, APEX, APX, HAP1, REF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27695 (4-284)
      • variant (5)
      • engineered mutation (104)
    Domains in SCOPe 2.08: d4qh9a_
  • Heterogens: EDO, MN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4qh9A (A:)
gshmasegpalyedppdqktspsgkpatlkicswnvdglrawikkkgldwvkeeapdilc
lqetkcsenklpaelqelpglshqywsapsdkegysgvgllsrqaplkvsygigdeehdq
egrvivaefdsfvlvtayvpnagrglvrleyrqrwdeafrkflkglasrkplvlcgdlnv
aheeidlrnpkgnkknagftpqerqgfgellqavpladsfrhlypntpyaytfwtymmna
rsknvgwrldyfllshsllpalcdskirskalgsdhcpitlylal

    Sequence, based on observed residues (ATOM records): (download) 
    >4qh9A (A:)
asegpalyedppdqktspsgkpatlkicswnvdglrawikkkgldwvkeeapdilclqet
kcsenklpaelqelpglshqywsapsdkegysgvgllsrqaplkvsygigdeehdqegrv
ivaefdsfvlvtayvpnagrglvrleyrqrwdeafrkflkglasrkplvlcgdlnvahee
idlrnpkgnkknagftpqerqgfgellqavpladsfrhlypntpyaytfwtymmnarskn
vgwrldyfllshsllpalcdskirskalgsdhcpitlylal