PDB entry 4qf1

View 4qf1 on RCSB PDB site
Description: Crystal structure of unliganded CH59UA, the inferred unmutated ancestor of the RV144 anti-HIV antibody lineage producing CH59
Class: immune system
Keywords: anti-HIV antibody, gp120, IMMUNE SYSTEM
Deposited on 2014-05-19, released 2015-02-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: CH59UA Fab fragment of heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4QF1 (0-End)
    Domains in SCOPe 2.08: d4qf1a_
  • Chain 'B':
    Compound: Inferred unmutated ancestor (UA) of anti-HIV antibody CH59
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4QF1 (0-End)
    Domains in SCOPe 2.08: d4qf1b1, d4qf1b2
  • Chain 'H':
    Compound: CH59UA Fab fragment of heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4QF1 (0-End)
    Domains in SCOPe 2.08: d4qf1h_
  • Chain 'L':
    Compound: Inferred unmutated ancestor (UA) of anti-HIV antibody CH59
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4QF1 (0-End)
    Domains in SCOPe 2.08: d4qf1l1, d4qf1l2
  • Heterogens: MES, PGE, CL, PG4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4qf1A (A:)
evqlvesggglvqpgrslrlscaasgftfddyamhwvrqapgkglewvsgiswnsgsigy
adsvkgrftisrdnaknslylqmnslraedtalyycakdsprgelpfdywgqgtlvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdk

    Sequence, based on observed residues (ATOM records): (download) 
    >4qf1A (A:)
evqlvesggglvqpgrslrlscaasgftfddyamhwvrqapgkglewvsgiswnsgsigy
adsvkgrftisrdnaknslylqmnslraedtalyycakdsprgelpfdywgqgtlvtvss
astkgpsvfplaptaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssv
vtvpssslgtqtyicnvnhkpsntkvdkrvep

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4qf1B (B:)
syeltqppsvsvspgqtaritcsgdalpkkyaywyqqksgqapvlviyedskrpsgiper
fsgsssgtmatltisgaqvedeadyycystdssgnhrvfgggtkltvlgqpkaapsvtlf
ppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyl
sltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >4qf1B (B:)
syeltqppsvsvspgqtaritcsgdalpkkyaywyqqksgqapvlviyedskrpsgiper
fsgsssgtmatltisgaqvedeadyycystdssgnhrvfgggtkltvlgqpkaapsvtlf
ppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyl
sltpeqwkshrsyscqvthegstvektvap

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4qf1H (H:)
evqlvesggglvqpgrslrlscaasgftfddyamhwvrqapgkglewvsgiswnsgsigy
adsvkgrftisrdnaknslylqmnslraedtalyycakdsprgelpfdywgqgtlvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdk

    Sequence, based on observed residues (ATOM records): (download) 
    >4qf1H (H:)
evqlvesggglvqpgrslrlscaasgftfddyamhwvrqapgkglewvsgiswnsgsigy
adsvkgrftisrdnaknslylqmnslraedtalyycakdsprgelpfdywgqgtlvtvss
astkgpsvfplaptaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssv
vtvpssslgtqtyicnvnhkpsntkvdkrvep

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >4qf1L (L:)
syeltqppsvsvspgqtaritcsgdalpkkyaywyqqksgqapvlviyedskrpsgiper
fsgsssgtmatltisgaqvedeadyycystdssgnhrvfgggtkltvlgqpkaapsvtlf
ppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyl
sltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >4qf1L (L:)
syeltqppsvsvspgqtaritcsgdalpkkyaywyqqksgqapvlviyedskrpsgiper
fsgsssgtmatltisgaqvedeadyycystdssgnhrvfgggtkltvlgqpkaapsvtlf
ppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyl
sltpeqwkshrsyscqvthegstvektvapt