PDB entry 4qci

View 4qci on RCSB PDB site
Description: PDGF-B blocking antibody bound to PDGF-BB
Class: cytokine/cytokine receptor
Keywords: growth factor cytokine fold, growth factor hormone, PDGFR-beta receptor, extracellular, CYTOKINE-CYTOKINE RECEPTOR complex
Deposited on 2014-05-12, released 2015-03-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-02-14, with a file datestamp of 2018-02-09.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: anti-PDGF-BB antibody - Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4QCI
    Domains in SCOPe 2.08: d4qcia1, d4qcia2
  • Chain 'B':
    Compound: anti-PDGF-BB antibody - Heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4QCI (0-End)
    Domains in SCOPe 2.08: d4qcib_
  • Chain 'C':
    Compound: Platelet-derived growth factor subunit B
    Species: Homo sapiens [TaxId:9606]
    Gene: PDGFB, PDGF2, SIS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4qcic_
  • Chain 'D':
    Compound: Platelet-derived growth factor subunit B
    Species: Homo sapiens [TaxId:9606]
    Gene: PDGFB, PDGF2, SIS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4qcid_
  • Chain 'H':
    Compound: anti-PDGF-BB antibody - Heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4QCI (0-End)
    Domains in SCOPe 2.08: d4qcih_
  • Chain 'L':
    Compound: anti-PDGF-BB antibody - Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4QCI
    Domains in SCOPe 2.08: d4qcil1, d4qcil2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4qciA (A:)
syeltqppsvsvapgqtariscsgdslgsyfvhwyqqkpgqapvlviyddsnrpsgiper
fsgsnsgntatltisgtqaedeadyycsafthnsdvfgggtkltvlpkstptltvfppss
eelkenkatlvclisnfspsgvtvawkangtpitqgvdtsnptkegnkfmassflhltsd
qwrshnsftcqvthegdtvekslspaecl

    Sequence, based on observed residues (ATOM records): (download) 
    >4qciA (A:)
yeltqppsvsvapgqtariscsgdslgsyfvhwyqqkpgqapvlviyddsnrpsgiperf
sgsnsgntatltisgtqaedeadyycsafthnsdvfgggtkltvlpkstptltvfppsse
elkenkatlvclisnfspsgvtvawkangtpitqgvdtsnptkegnkfmassflhltsdq
wrshnsftcqvthegdtvekslspae

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4qciB (B:)
evqlvesggglvqpggslrlscaasgftfssyamswvrqapgkglewvsyisddgslkyy
adsvkgrftisrdnskntlylqmnslraedtavyycarhpywyggqldlwgqgtlvtvss
akttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsd
lytlsssvtvpsstwpsetvtcnvahpasstkvdkkivprdcg

    Sequence, based on observed residues (ATOM records): (download) 
    >4qciB (B:)
evqlvesggglvqpggslrlscaasgftfssyamswvrqapgkglewvsyisddgslkyy
adsvkgrftisrdnskntlylqmnslraedtavyycarhpywyggqldlwgqgtlvtvss
akttppsvyplapgsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytlss
svtvpsstwpsetvtcnvahpasstkvdkkivpr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4qciC (C:)
mslgsltiaepamiaecktrtevfeisrrlidrtnanflvwppcvevqrcsgccnnrnvq
crptqvqlrpvqvrkieivrkkpifkkatvtledhlackcetvaaarpvt

    Sequence, based on observed residues (ATOM records): (download) 
    >4qciC (C:)
pamiaecktrtevfeisrrlidrtnanflvwppcvevqrcsgccnnrnvqcrptqvqlrp
vqvrkieivrkkpifkkatvtledhlackcet

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4qciD (D:)
mslgsltiaepamiaecktrtevfeisrrlidrtnanflvwppcvevqrcsgccnnrnvq
crptqvqlrpvqvrkieivrkkpifkkatvtledhlackcetvaaarpvt

    Sequence, based on observed residues (ATOM records): (download) 
    >4qciD (D:)
iaepamiaecktrtevfeisrrlidrtnanflvwppcvevqrcsgccnnrnvqcrptqvq
lrpvqvrkieivrkkpifkkatvtledhlackcetv

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4qciH (H:)
evqlvesggglvqpggslrlscaasgftfssyamswvrqapgkglewvsyisddgslkyy
adsvkgrftisrdnskntlylqmnslraedtavyycarhpywyggqldlwgqgtlvtvss
akttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsd
lytlsssvtvpsstwpsetvtcnvahpasstkvdkkivprdcg

    Sequence, based on observed residues (ATOM records): (download) 
    >4qciH (H:)
evqlvesggglvqpggslrlscaasgftfssyamswvrqapgkglewvsyisddgslkyy
adsvkgrftisrdnskntlylqmnslraedtavyycarhpywyggqldlwgqgtlvtvss
akttppsvyplapmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytlsssv
tvpvtcnvahpasstkvdkkivpr

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >4qciL (L:)
syeltqppsvsvapgqtariscsgdslgsyfvhwyqqkpgqapvlviyddsnrpsgiper
fsgsnsgntatltisgtqaedeadyycsafthnsdvfgggtkltvlpkstptltvfppss
eelkenkatlvclisnfspsgvtvawkangtpitqgvdtsnptkegnkfmassflhltsd
qwrshnsftcqvthegdtvekslspaecl

    Sequence, based on observed residues (ATOM records): (download) 
    >4qciL (L:)
eltqppsvsvapgqtariscsgdslgsyfvhwyqqkpgqapvlviyddsnrpsgiperfs
gsnsgntatltisgtqaedeadyycsafthnsdvfgggtkltvlpkstptltvfppssee
lkenkatlvclisnfspsgvtvawkangtpitqgvdtsnptkegnkfmassflhltsdqw
rshnsftcqvthegdtvekslsp