PDB entry 4qag

View 4qag on RCSB PDB site
Description: Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNASE H domain of HIV-1 reverse transcriptase
Class: hydrolase/hydrolase inhibitor
Keywords: RNASE H INHIBITOR, STRUCTURE-BASED DRUG DESIGN, ACTIVE SITE, TRANSFERASE, DIHYDROXYCOUMARIN ANALOGS, DIHYDROXY-BENZOPYRONE DERIVATIVES, DIVALENT CATION CHELATOR, AIDS, REVERSE TRANSCRIPTASE, PROTEIN-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2014-05-04, released 2014-06-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-07-09, with a file datestamp of 2014-07-03.
Experiment type: XRAY
Resolution: 1.71 Å
R-factor: 0.183
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Reverse transcriptase/ribonuclease H
  Species: Human immunodeficiency virus type 1 [TaxId:11678]
  Gene: gag-pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03366 (0-132)
  Domains in SCOPe 2.08: d4qaga_
• Chain 'B':
  Compound: Reverse transcriptase/ribonuclease H
  Species: Human immunodeficiency virus type 1 [TaxId:11678]
  Gene: gag-pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03366 (0-132)
  Domains in SCOPe 2.08: d4qagb_
• Heterogens: MN, F95, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4qagA (A:)
  lwyqlekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqktelqaiyl
  alqdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgigg
  neqvdklvsagir
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4qagB (B:)
  lwyqlekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqktelqaiyl
  alqdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgigg
  neqvdklvsagir