PDB entry 4qa6

View 4qa6 on RCSB PDB site
Description: Crystal structure of I243N/Y306F HDAC8 in complex with a tetrapeptide substrate
Deposited on 2014-05-02, released 2014-08-06
The last revision was dated 2014-10-01, with a file datestamp of 2014-09-26.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.182
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase 8
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC8, HDACL1, CDA07
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BY41 (Start-376)
      • engineered mutation (242)
      • engineered mutation (305)
  • Chain 'B':
    Compound: Histone deacetylase 8
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC8, HDACL1, CDA07
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BY41 (Start-376)
      • engineered mutation (242)
      • engineered mutation (305)
  • Chain 'C':
    Compound: tetrapeptide substrate
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 4QA6 (Start-3)
  • Chain 'D':
    Compound: tetrapeptide substrate
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 4QA6 (Start-3)
  • Heterogens: ZN, K, GOL, MCM, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4qa6A (A:)
meepeepadsgqslvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpk
vasmeematfhtdaylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggati
taaqclidgmckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlh
hgdgvedafsftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdeky
yqncesvlkevyqafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatli
lggggfnlantarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrneph
riqqilnyikgnlkhvviegrgshhhhhh

    Sequence, based on observed residues (ATOM records):
    >4qa6A (A:)
lvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggatitaaqclidgmckv
ainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsfts
kvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqncesvlkevyq
afnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggfnlantar
cwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnl
khvv

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4qa6B (B:)
meepeepadsgqslvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpk
vasmeematfhtdaylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggati
taaqclidgmckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlh
hgdgvedafsftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdeky
yqncesvlkevyqafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatli
lggggfnlantarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrneph
riqqilnyikgnlkhvviegrgshhhhhh

    Sequence, based on observed residues (ATOM records):
    >4qa6B (B:)
lvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggatitaaqclidgmckv
ainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsfts
kvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqncesvlkevyq
afnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggfnlantar
cwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnl
khvv

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >4qa6C (C:)
rhkk

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >4qa6D (D:)
rhkk