PDB entry 4qa5

View 4qa5 on RCSB PDB site
Description: Crystal structure of A188T/Y306F HDAC8 in complex with a tetrapeptide substrate
Deposited on 2014-05-02, released 2014-08-06
The last revision was dated 2014-10-01, with a file datestamp of 2014-09-26.
Experiment type: XRAY
Resolution: 1.76 Å
R-factor: 0.169
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase 8
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC8, HDACL1, CDA07
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BY41 (Start-376)
      • engineered mutation (187)
      • engineered mutation (305)
  • Chain 'B':
    Compound: Histone deacetylase 8
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC8, HDACL1, CDA07
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BY41 (Start-376)
      • engineered mutation (187)
      • engineered mutation (305)
      • expression tag (377-380)
  • Chain 'C':
    Compound: tetrapeptide substrate
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 4QA5 (Start-3)
  • Chain 'D':
    Compound: tetrapeptide substrate
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 4QA5 (Start-3)
  • Heterogens: ZN, K, GOL, MG, MCM, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4qa5A (A:)
meepeepadsgqslvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpk
vasmeematfhtdaylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggati
taaqclidgmckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlh
hgdgvedtfsftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdeky
yqicesvlkevyqafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatli
lggggfnlantarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrneph
riqqilnyikgnlkhvviegrgshhhhhh

    Sequence, based on observed residues (ATOM records):
    >4qa5A (A:)
lvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggatitaaqclidgmckv
ainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedtfsfts
kvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyq
afnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggfnlantar
cwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnl
khvv

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4qa5B (B:)
meepeepadsgqslvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpk
vasmeematfhtdaylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggati
taaqclidgmckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlh
hgdgvedtfsftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdeky
yqicesvlkevyqafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatli
lggggfnlantarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrneph
riqqilnyikgnlkhvviegrgshhhhhh

    Sequence, based on observed residues (ATOM records):
    >4qa5B (B:)
slvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfht
daylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggatitaaqclidgmck
vainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedtfsft
skvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevy
qafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggfnlanta
rcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgn
lkhvviegr

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >4qa5C (C:)
rhkk

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >4qa5D (D:)
rhkk