PDB entry 4q6r

View 4q6r on RCSB PDB site
Description: Crystal structure of human sphingosine-1-phosphate lyase in complex with inhibitor 6-[(2R)-4-(4-benzyl-7-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile
Deposited on 2014-04-23, released 2014-05-21
The last revision was dated 2014-07-23, with a file datestamp of 2014-07-18.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.179
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Sphingosine-1-phosphate lyase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: KIAA1252, SGPL1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Sphingosine-1-phosphate lyase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: KIAA1252, SGPL1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: SIN, GOL, 30J, PO4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4q6rA (A:)
gpgsqpeslwsrfkkkcfkltrkmpiigrkiqdklnktkddisknmsflkvdkeyvkalp
sqglsssavleklkeyssmdafwqegrasgtvysgeekltellvkaygdfawsnplhpdi
fpglrkieaeivriacslfnggpdscgcvtsggtesilmackayrdlafekgiktpeiva
pqsahaafnkaasyfgmkivrvpltkmmevdvramrraisrntamlvcstpqfphgvidp
vpevaklavkykiplhvdaclggflivfmekagyplehpfdfrvkgvtsisadthkygya
pkgsslvlysdkkyrnyqffvdtdwqggiyasptiagsrpggisaacwaalmhfgengyv
eatkqiiktarflkselenikgifvfgnpqlsvialgsrdfdiyrlsnlmtakgwnlnql
qfppsihfcitllharkrvaiqflkdiresvtqimknpkakttgmgaiygmaqttvdrnm
vaelssvfldslystdtvtqgsqmngspkph

    Sequence, based on observed residues (ATOM records):
    >4q6rA (A:)
eyvkalpsqglsssavleklkeyssmdafwqegrasgtvysgeekltellvkaygdfaws
nplhpdifpglrkieaeivriacslfnggpdscgcvtsggtesilmackayrdlafekgi
ktpeivapqsahaafnkaasyfgmkivrvpltkmmevdvramrraisrntamlvcstpqf
phgvidpvpevaklavkykiplhvdaclggflivfmekagyplehpfdfrvkgvtsisad
thkygyapkgsslvlysdkkyrnyqffvdtdwqggiyasptiagsrpggisaacwaalmh
fgengyveatkqiiktarflkselenikgifvfgnpqlsvialgsrdfdiyrlsnlmtak
gwnlnqlqfppsihfcitllharkrvaiqflkdiresvtqimknpkakttgmgaiygmaq
ttvdrnmvaelssvfldslystd

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4q6rB (B:)
gpgsqpeslwsrfkkkcfkltrkmpiigrkiqdklnktkddisknmsflkvdkeyvkalp
sqglsssavleklkeyssmdafwqegrasgtvysgeekltellvkaygdfawsnplhpdi
fpglrkieaeivriacslfnggpdscgcvtsggtesilmackayrdlafekgiktpeiva
pqsahaafnkaasyfgmkivrvpltkmmevdvramrraisrntamlvcstpqfphgvidp
vpevaklavkykiplhvdaclggflivfmekagyplehpfdfrvkgvtsisadthkygya
pkgsslvlysdkkyrnyqffvdtdwqggiyasptiagsrpggisaacwaalmhfgengyv
eatkqiiktarflkselenikgifvfgnpqlsvialgsrdfdiyrlsnlmtakgwnlnql
qfppsihfcitllharkrvaiqflkdiresvtqimknpkakttgmgaiygmaqttvdrnm
vaelssvfldslystdtvtqgsqmngspkph

    Sequence, based on observed residues (ATOM records):
    >4q6rB (B:)
keyvkalpsqglsssavleklkeyssmdafwqegrasgtvysgeekltellvkaygdfaw
snplhpdifpglrkieaeivriacslfnggpdscgcvtsggtesilmackayrdlafekg
iktpeivapqsahaafnkaasyfgmkivrvpltkmmevdvramrraisrntamlvcstpq
fphgvidpvpevaklavkykiplhvdaclggflivfmekagyplehpfdfrvkgvtsisa
dthkygyapkgsslvlysdkkyrnyqffvdtdwqggiyasptiagsrpggisaacwaalm
hfgengyveatkqiiktarflkselenikgifvfgnpqlsvialgsrdfdiyrlsnlmta
kgwnlnqlqfppsihfcitllharkrvaiqflkdiresvtqimknpkakttgmgaiygma
qttvdrnmvaelssvfldslystd