PDB entry 4q5v

View 4q5v on RCSB PDB site
Description: Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an RNA-primed DNA template and aphidicolin
Deposited on 2014-04-17, released 2014-11-26
The last revision was dated 2015-01-07, with a file datestamp of 2015-01-02.
Experiment type: XRAY
Resolution: 2.52 Å
R-factor: 0.233
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA polymerase alpha catalytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: POLA1, POLA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09884
      • engineered mutation (180)
  • Chain 'B':
    Compound: RNA primer
  • Chain 'C':
    Compound: DNA Template
  • Chain 'E':
    Compound: DNA polymerase alpha catalytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: POLA1, POLA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09884
      • engineered mutation (180)
  • Chain 'F':
    Compound: RNA primer
  • Chain 'G':
    Compound: DNA Template
  • Heterogens: 2ZE, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4q5vA (A:)
deeqvfhfywldayedqynqpgvvflfgkvwiesaethvsccvmvkniertlyflpremk
idlntgketgtpismkdvyeefdekiatkykimkfkskpveknyafeipdvpekseylev
kysaempqlpqdlkgetfshvfgtntsslelflmnrkikgpcwlevkspqllnqpvswck
aeamalkpdlvnvikdvsppplvvmafsmktmqnaknhqneiiamaalvhhsfaldkaap
kppfqshfcvvskpkdcifpyafkeviekknvkvevaatertllgfflakvhkidpdiiv
ghniygfelevllqrinvckaphwskigrlkrsnmpklggrsgfgernatcgrmicdvei
sakelircksyhlselvqqilktervvipmeniqnmysessqllyllehtwkdakfilqi
mcelnvlplalqitniagnimsrtlmggrserneflllhafyennyivpdkqifrkpqqk
lgdedeeidgdtnkykkgrkkaayagglvldpkvgfydkfillldfnslypsiiqefnic
fttvqrvaseaqkvtedgeqeqipelpdpslemgilpreirklverrkqvkqlmkqqdln
pdlilqydirqkalkltansmygclgfsysrfyakplaalvtykgreilmhtkemvqkmn
leviygdtdsimintnstnleevfklgnkvksevnklyklleididgvfksllllkkkky
aalvveptsdgnyvtkqelkgldivrrdwcdlakdtgnfvigqilsdqsrdtiveniqkr
lieigenvlngsvpvsqfeinkaltkdpqdypdkkslphvhvalwinsqggrkvkagdtv
syvicqdgsnltasqrayapeqlqkqdnltidtqyylaqqihpvvaricepidgidavli
atwlgldptqfrvhhyhkdeen

    Sequence, based on observed residues (ATOM records):
    >4q5vA (A:)
eqvfhfywldayedqynqpgvvflfgkvwiesaethvsccvmvkniertlyflpremkid
lntgketgtpismkdvyeefdekiatkykimkfkskpveknyafeipdvpekseylevky
saempqlpqdlkgetfshvfgtntsslelflmnrkikgpcwlevkspqllnqpvswckae
amalkpdlvnvikdvsppplvvmafsmktmqnaknhqneiiamaalvhhsfaldkaapkp
pfqshfcvvskpkdcifpyafkeviekknvkvevaatertllgfflakvhkidpdiivgh
niygfelevllqrinvckaphwskigrlkrsnmpklgfgernatcgrmicdveisakeli
rcksyhlselvqqilktervvipmeniqnmysessqllyllehtwkdakfilqimcelnv
lplalqitniagnimsrtlmggrserneflllhafyennyivpdkqirkkaayagglvld
pkvgfydkfillldfnslypsiiqefnicfttvqrveqipelpdpslemgilpreirklv
errkqvkqlmkqqdlnpdlilqydirqkalkltansmygclgfsysrfyakplaalvtyk
greilmhtkemvqkmnleviygdtdsimintnstnleevfklgnkvksevnklyklleid
idgvfksllllkkkkyaalvveptsdgnyvtkqelkgldivrrdwcdlakdtgnfvigqi
lsdqsrdtiveniqkrlieigenvlngsvpvsqfeinkaltkdpqdypdkkslphvhval
winsqggrkvkagdtvsyvicqdgsnltasqrayapeqlqkqdnltidtqyylaqqihpv
varicepidgidavliatwlgldpt

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records:
    >4q5vE (E:)
deeqvfhfywldayedqynqpgvvflfgkvwiesaethvsccvmvkniertlyflpremk
idlntgketgtpismkdvyeefdekiatkykimkfkskpveknyafeipdvpekseylev
kysaempqlpqdlkgetfshvfgtntsslelflmnrkikgpcwlevkspqllnqpvswck
aeamalkpdlvnvikdvsppplvvmafsmktmqnaknhqneiiamaalvhhsfaldkaap
kppfqshfcvvskpkdcifpyafkeviekknvkvevaatertllgfflakvhkidpdiiv
ghniygfelevllqrinvckaphwskigrlkrsnmpklggrsgfgernatcgrmicdvei
sakelircksyhlselvqqilktervvipmeniqnmysessqllyllehtwkdakfilqi
mcelnvlplalqitniagnimsrtlmggrserneflllhafyennyivpdkqifrkpqqk
lgdedeeidgdtnkykkgrkkaayagglvldpkvgfydkfillldfnslypsiiqefnic
fttvqrvaseaqkvtedgeqeqipelpdpslemgilpreirklverrkqvkqlmkqqdln
pdlilqydirqkalkltansmygclgfsysrfyakplaalvtykgreilmhtkemvqkmn
leviygdtdsimintnstnleevfklgnkvksevnklyklleididgvfksllllkkkky
aalvveptsdgnyvtkqelkgldivrrdwcdlakdtgnfvigqilsdqsrdtiveniqkr
lieigenvlngsvpvsqfeinkaltkdpqdypdkkslphvhvalwinsqggrkvkagdtv
syvicqdgsnltasqrayapeqlqkqdnltidtqyylaqqihpvvaricepidgidavli
atwlgldptqfrvhhyhkdeen

    Sequence, based on observed residues (ATOM records):
    >4q5vE (E:)
eqvfhfywldayedqynqpgvvflfgkvwiesaethvsccvmvkniertlyflpremkid
lntgketgtpismkdvyeefdekiatkykimkfkskpveknyafeipdvpekseylevky
saempqlpqdlkgetfshvfgtntsslelflmnrkikgpcwlevkspqllnqpvswckae
amalkpdlvnvikdvsppplvvmafsmktmqnaknhqneiiamaalvhhsfaldkaapkp
pfqshfcvvskpkdcifpyafkeviekknvkvevaatertllgfflakvhkidpdiivgh
niygfelevllqrinvckaphwskigrlkrsnmpklgfgernatcgrmicdveisakeli
rcksyhlselvqqilktervvipmeniqnmysessqllyllehtwkdakfilqimcelnv
lplalqitniagnimsrtlmggrserneflllhafyennyivpdkqirkkaayagglvld
pkvgfydkfillldfnslypsiiqefnicfttvqrveqipelpdpslemgilpreirklv
errkqvkqlmkqqdlnpdlilqydirqkalkltansmygclgfsysrfyakplaalvtyk
greilmhtkemvqkmnleviygdtdsimintnstnleevfklgnkvksevnklyklleid
idgvfksllllkkkkyaalvveptsdgnyvtkqelkgldivrrdwcdlakdtgnfvigqi
lsdqsrdtiveniqkrlieigenvlngsvpvsqfeinkaltkdpqdypdkkslphvhval
winsqggrkvkagdtvsyvicqdgsnltasqrayapeqlqkqdnltidtqyylaqqihpv
varicepidgidavliatwlgldpt

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.