PDB entry 4q3t

View 4q3t on RCSB PDB site
Description: Crystal structure of Schistosoma mansoni arginase in complex with inhibitor NOHA
Class: hydrolase/hydrolase inhibitor
Keywords: arginase-deacetylase fold, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2014-04-12, released 2014-07-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-08-06, with a file datestamp of 2014-08-01.
Experiment type: XRAY
Resolution: 2.14 Å
R-factor: 0.178
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: arginase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: Smp_059980
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4q3ta_
  • Chain 'B':
    Compound: arginase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: Smp_059980
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4q3tb_
  • Chain 'C':
    Compound: arginase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: Smp_059980
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4q3tc_
  • Chain 'D':
    Compound: arginase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: Smp_059980
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4q3td_
  • Heterogens: MN, GOL, HAR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4q3tA (A:)
mgsshhhhhhssglvprgshmmlksvatpyypiqdekpkllytsanflgiptnrgqpkig
tyqgpelirksnffqlvaedgiqltdcgdiipvelneaedpqrfgmkwsrsfslttlria
erveelmkqsnkhtvelsgskstplvivggdhsmatgtilghaeakpdlcvlwidahgdi
ntplnsasgnmhgmplsflvkelqdqipwlddfegikpclnasniayiglrdldahethd
irkhgiayftmldvdrmgieavikeallavnprlekaihlsfdidaldplvapstgtavp
ggltlreglriceevsatgklsvvelaelnpllgsqedvlktqssavhilraclghcrsg
hlpfkvrnltdqgimsraahmqtkq

    Sequence, based on observed residues (ATOM records): (download) 
    >4q3tA (A:)
pkllytsanflgiptnrgqpkigtyqgpelirksnffqlvaedgiqltdcgdiipvelne
aedpqrfgmkwsrsfslttlriaerveelmkqsnkstplvivggdhsmatgtilghaeak
pdlcvlwidahgdintplnsasgnmhgmplsflvkelqdqipwlddfegikpclnasnia
yiglrdldahethdirkhgiayftmldvdrmgieavikeallavnprlekaihlsfdida
ldplvapstgtavpggltlreglriceevsatgklsvvelaelnpllgsqedvlktqssa
vhilraclghcrsghlpfkvrnltdqgimsraahmq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4q3tB (B:)
mgsshhhhhhssglvprgshmmlksvatpyypiqdekpkllytsanflgiptnrgqpkig
tyqgpelirksnffqlvaedgiqltdcgdiipvelneaedpqrfgmkwsrsfslttlria
erveelmkqsnkhtvelsgskstplvivggdhsmatgtilghaeakpdlcvlwidahgdi
ntplnsasgnmhgmplsflvkelqdqipwlddfegikpclnasniayiglrdldahethd
irkhgiayftmldvdrmgieavikeallavnprlekaihlsfdidaldplvapstgtavp
ggltlreglriceevsatgklsvvelaelnpllgsqedvlktqssavhilraclghcrsg
hlpfkvrnltdqgimsraahmqtkq

    Sequence, based on observed residues (ATOM records): (download) 
    >4q3tB (B:)
pkllytsanflgiptnrgqpkigtyqgpelirksnffqlvaedgiqltdcgdiipvelne
aedpqrfgmkwsrsfslttlriaerveelmkqsstplvivggdhsmatgtilghaeakpd
lcvlwidahgdintplnsasgnmhgmplsflvkelqdqipwlddfegikpclnasniayi
glrdldahethdirkhgiayftmldvdrmgieavikeallavnprlekaihlsfdidald
plvapstgtavpggltlreglriceevsatgklsvvelaelnpllgsqedvlktqssavh
ilraclghcrsghlpfkvrnltdqgimsraahmqt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4q3tC (C:)
mgsshhhhhhssglvprgshmmlksvatpyypiqdekpkllytsanflgiptnrgqpkig
tyqgpelirksnffqlvaedgiqltdcgdiipvelneaedpqrfgmkwsrsfslttlria
erveelmkqsnkhtvelsgskstplvivggdhsmatgtilghaeakpdlcvlwidahgdi
ntplnsasgnmhgmplsflvkelqdqipwlddfegikpclnasniayiglrdldahethd
irkhgiayftmldvdrmgieavikeallavnprlekaihlsfdidaldplvapstgtavp
ggltlreglriceevsatgklsvvelaelnpllgsqedvlktqssavhilraclghcrsg
hlpfkvrnltdqgimsraahmqtkq

    Sequence, based on observed residues (ATOM records): (download) 
    >4q3tC (C:)
pkllytsanflgiptnrgqpkigtyqgpelirksnffqlvaedgiqltdcgdiipvelne
aedpqrfgmkwsrsfslttlriaerveelmkqstplvivggdhsmatgtilghaeakpdl
cvlwidahgdintplnsasgnmhgmplsflvkelqdqipwlddfegikpclnasniayig
lrdldahethdirkhgiayftmldvdrmgieavikeallavnprlekaihlsfdidaldp
lvapstgtavpggltlreglriceevsatgklsvvelaelnpllgsqedvlktqssavhi
lraclghcrsghlpfkvrnltdqgimsraahmqt

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4q3tD (D:)
mgsshhhhhhssglvprgshmmlksvatpyypiqdekpkllytsanflgiptnrgqpkig
tyqgpelirksnffqlvaedgiqltdcgdiipvelneaedpqrfgmkwsrsfslttlria
erveelmkqsnkhtvelsgskstplvivggdhsmatgtilghaeakpdlcvlwidahgdi
ntplnsasgnmhgmplsflvkelqdqipwlddfegikpclnasniayiglrdldahethd
irkhgiayftmldvdrmgieavikeallavnprlekaihlsfdidaldplvapstgtavp
ggltlreglriceevsatgklsvvelaelnpllgsqedvlktqssavhilraclghcrsg
hlpfkvrnltdqgimsraahmqtkq

    Sequence, based on observed residues (ATOM records): (download) 
    >4q3tD (D:)
llytsanflgiptnrgqpkigtyqgpelirksnffqlvaedgiqltdcgdiipvelneae
dpqrfgmkwsrsfslttlriaerveelmkqstplvivggdhsmatgtilghaeakpdlcv
lwidahgdintplnsasgnmhgmplsflvkelqdqipwlddfegikpclnasniayiglr
dldahethdirkhgiayftmldvdrmgieavikeallavnprlekaihlsfdidaldplv
apstgtavpggltlreglriceevsatgklsvvelaelnpllgsqedvlktqssavhilr
aclghcrsghlpfkvrnltdqgimsraah