PDB entry 4q3s

View 4q3s on RCSB PDB site
Description: Crystal structure of Schistosoma mansoni arginase in complex with inhibitor ABHPE
Class: hydrolase/hydrolase inhibitor
Keywords: arginase-deacetylase fold, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2014-04-12, released 2014-07-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-08-06, with a file datestamp of 2014-08-01.
Experiment type: XRAY
Resolution: 2.11 Å
R-factor: 0.175
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: arginase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: Smp_059980
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4q3sa_
  • Chain 'B':
    Compound: arginase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: Smp_059980
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4q3sb_
  • Chain 'C':
    Compound: arginase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: Smp_059980
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4q3sc_
  • Chain 'D':
    Compound: arginase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: Smp_059980
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4q3sd_
  • Heterogens: MN, X7A, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4q3sA (A:)
mgsshhhhhhssglvprgshmmlksvatpyypiqdekpkllytsanflgiptnrgqpkig
tyqgpelirksnffqlvaedgiqltdcgdiipvelneaedpqrfgmkwsrsfslttlria
erveelmkqsnkhtvelsgskstplvivggdhsmatgtilghaeakpdlcvlwidahgdi
ntplnsasgnmhgmplsflvkelqdqipwlddfegikpclnasniayiglrdldahethd
irkhgiayftmldvdrmgieavikeallavnprlekaihlsfdidaldplvapstgtavp
ggltlreglriceevsatgklsvvelaelnpllgsqedvlktqssavhilraclghcrsg
hlpfkvrnltdqgimsraahmqtkq

    Sequence, based on observed residues (ATOM records): (download) 
    >4q3sA (A:)
kllytsanflgiptnrgqpkigtyqgpelirksnffqlvaedgiqltdcgdiipvelnea
edpqrfgmkwsrsfslttlriaerveelmkqsnkstplvivggdhsmatgtilghaeakp
dlcvlwidahgdintplnsasgnmhgmplsflvkelqdqipwlddfegikpclnasniay
iglrdldahethdirkhgiayftmldvdrmgieavikeallavnprlekaihlsfdidal
dplvapstgtavpggltlreglriceevsatgklsvvelaelnpllgsqedvlktqssav
hilraclghcrsghlpfkvrnltdqgimsraahmq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4q3sB (B:)
mgsshhhhhhssglvprgshmmlksvatpyypiqdekpkllytsanflgiptnrgqpkig
tyqgpelirksnffqlvaedgiqltdcgdiipvelneaedpqrfgmkwsrsfslttlria
erveelmkqsnkhtvelsgskstplvivggdhsmatgtilghaeakpdlcvlwidahgdi
ntplnsasgnmhgmplsflvkelqdqipwlddfegikpclnasniayiglrdldahethd
irkhgiayftmldvdrmgieavikeallavnprlekaihlsfdidaldplvapstgtavp
ggltlreglriceevsatgklsvvelaelnpllgsqedvlktqssavhilraclghcrsg
hlpfkvrnltdqgimsraahmqtkq

    Sequence, based on observed residues (ATOM records): (download) 
    >4q3sB (B:)
kllytsanflgiptnrgqpkigtyqgpelirksnffqlvaedgiqltdcgdiipvelnea
edpqrfgmkwsrsfslttlriaerveelmkqsnkstplvivggdhsmatgtilghaeakp
dlcvlwidahgdintplnsasgnmhgmplsflvkelqdqipwlddfegikpclnasniay
iglrdldahethdirkhgiayftmldvdrmgieavikeallavnprlekaihlsfdidal
dplvapstgtavpggltlreglriceevsatgklsvvelaelnpllgsqedvlktqssav
hilraclghcrsghlpfkvrnltdqgimsraahmq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4q3sC (C:)
mgsshhhhhhssglvprgshmmlksvatpyypiqdekpkllytsanflgiptnrgqpkig
tyqgpelirksnffqlvaedgiqltdcgdiipvelneaedpqrfgmkwsrsfslttlria
erveelmkqsnkhtvelsgskstplvivggdhsmatgtilghaeakpdlcvlwidahgdi
ntplnsasgnmhgmplsflvkelqdqipwlddfegikpclnasniayiglrdldahethd
irkhgiayftmldvdrmgieavikeallavnprlekaihlsfdidaldplvapstgtavp
ggltlreglriceevsatgklsvvelaelnpllgsqedvlktqssavhilraclghcrsg
hlpfkvrnltdqgimsraahmqtkq

    Sequence, based on observed residues (ATOM records): (download) 
    >4q3sC (C:)
kllytsanflgiptnrgqpkigtyqgpelirksnffqlvaedgiqltdcgdiipvelnea
edpqrfgmkwsrsfslttlriaerveelmkqstplvivggdhsmatgtilghaeakpdlc
vlwidahgdintplnsasgnmhgmplsflvkelqdqipwlddfegikpclnasniayigl
rdldahethdirkhgiayftmldvdrmgieavikeallavnprlekaihlsfdidaldpl
vapstgtavpggltlreglriceevsatgklsvvelaelnpllgsqedvlktqssavhil
raclghcrsghlpfkvrnltdqgimsraahmq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4q3sD (D:)
mgsshhhhhhssglvprgshmmlksvatpyypiqdekpkllytsanflgiptnrgqpkig
tyqgpelirksnffqlvaedgiqltdcgdiipvelneaedpqrfgmkwsrsfslttlria
erveelmkqsnkhtvelsgskstplvivggdhsmatgtilghaeakpdlcvlwidahgdi
ntplnsasgnmhgmplsflvkelqdqipwlddfegikpclnasniayiglrdldahethd
irkhgiayftmldvdrmgieavikeallavnprlekaihlsfdidaldplvapstgtavp
ggltlreglriceevsatgklsvvelaelnpllgsqedvlktqssavhilraclghcrsg
hlpfkvrnltdqgimsraahmqtkq

    Sequence, based on observed residues (ATOM records): (download) 
    >4q3sD (D:)
llytsanflgiptnrgqpkigtyqgpelirksnffqlvaedgiqltdcgdiipvelneae
dpqrfgmkwsrsfslttlriaerveelmkqsstplvivggdhsmatgtilghaeakpdlc
vlwidahgdintplnsasgnmhgmplsflvkelqdqipwlddfegikpclnasniayigl
rdldahethdirkhgiayftmldvdrmgieavikeallavnprlekaihlsfdidaldpl
vapstgtavpggltlreglriceevsatgklsvvelaelnpllgsqedvlktqssavhil
raclghcrsghlpfkvrnltdqgimsraahm