PDB entry 4q19

View 4q19 on RCSB PDB site
Description: Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 5 {5-(4-{[(4,6-DIAMINOPYRIMIDIN-2-YL)SULFANYL]METHYL}-5-PROPYL-1,3-THIAZOL-2-YL)-2-METHOXYPHENOL}
Class: transferase/transferase inhibitor
Keywords: PHOSPHORYL TRANSFER, PHOSPHORYLATION, DEOXYCYTIDINE, TRANSFERASE, INHIBITOR COMPLEX, kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2014-04-03, released 2014-11-05
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-11-05, with a file datestamp of 2014-10-31.
Experiment type: XRAY
Resolution: 2.09 Å
R-factor: 0.231
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707 (Start-279)
      • engineered mutation (64)
      • engineered mutation (78)
      • engineered mutation (93)
      • engineered mutation (165)
    Domains in SCOPe 2.04: d4q19a_
  • Chain 'B':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707 (Start-279)
      • engineered mutation (64)
      • engineered mutation (78)
      • engineered mutation (93)
      • engineered mutation (165)
  • Heterogens: 2XL, UDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4q19A (A:)
    mgsshhhhhhssglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvni
    lkqlsedwevvpepvarwsnvqstqdefeeltmeqknggnvlqmmyekperwsftfqtya
    clsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetewtiyqdwhd
    wmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrt
    lktnfdylqevpiltldvnedfkdkyeslvekvkeflstl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4q19A (A:)
    ikkisiegniaagkstfvnilkqlsedwevvpepvarwsltmeqknggnvlqmmyekper
    wsftfqtyaclsriraqlaslgklkdaekpvlffersvysdryifasnlyesesmnetew
    tiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykh
    eswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkeflstl
    

  • Chain 'B':
    No sequence available.