PDB entry 4q19
View 4q19 on RCSB PDB site
Description: Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 5 {5-(4-{[(4,6-DIAMINOPYRIMIDIN-2-YL)SULFANYL]METHYL}-5-PROPYL-1,3-THIAZOL-2-YL)-2-METHOXYPHENOL}
Class: transferase/transferase inhibitor
Keywords: PHOSPHORYL TRANSFER, PHOSPHORYLATION, DEOXYCYTIDINE, TRANSFERASE, INHIBITOR COMPLEX, kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2014-04-03, released
2014-11-05
The last revision prior to the SCOPe 2.04 freeze date was dated
2014-11-05, with a file datestamp of
2014-10-31.
Experiment type: XRAY
Resolution: 2.09 Å
R-factor: 0.231
AEROSPACI score: 0.29
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Deoxycytidine kinase
Species: Homo sapiens [TaxId:9606]
Gene: DCK
Database cross-references and differences (RAF-indexed):
- Uniprot P27707 (Start-279)
- engineered mutation (64)
- engineered mutation (78)
- engineered mutation (93)
- engineered mutation (165)
Domains in SCOPe 2.04: d4q19a_ - Chain 'B':
Compound: Deoxycytidine kinase
Species: Homo sapiens [TaxId:9606]
Gene: DCK
Database cross-references and differences (RAF-indexed):
- Uniprot P27707 (Start-279)
- engineered mutation (64)
- engineered mutation (78)
- engineered mutation (93)
- engineered mutation (165)
- Heterogens: 2XL, UDP, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4q19A (A:)
mgsshhhhhhssglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvni
lkqlsedwevvpepvarwsnvqstqdefeeltmeqknggnvlqmmyekperwsftfqtya
clsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetewtiyqdwhd
wmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrt
lktnfdylqevpiltldvnedfkdkyeslvekvkeflstl
Sequence, based on observed residues (ATOM records): (download)
>4q19A (A:)
ikkisiegniaagkstfvnilkqlsedwevvpepvarwsltmeqknggnvlqmmyekper
wsftfqtyaclsriraqlaslgklkdaekpvlffersvysdryifasnlyesesmnetew
tiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykh
eswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkeflstl
- Chain 'B':
No sequence available.