PDB entry 4q07

View 4q07 on RCSB PDB site
Description: Crystal structure of chimeric carbonic anhydrase IX with inhibitor
Class: lyase/lyase inhibitor
Keywords: drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex
Deposited on 2014-04-01, released 2015-01-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-03-07, with a file datestamp of 2018-03-02.
Experiment type: XRAY
Resolution: 1.15 Å
R-factor: N/A
AEROSPACI score: 0.68 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carbonic anhydrase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CA2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00918 (Start-259)
      • engineered mutation (64)
      • engineered mutation (66)
      • engineered mutation (90)
      • engineered mutation (129)
      • engineered mutation (133)
      • engineered mutation (202)
    Domains in SCOPe 2.08: d4q07a_
  • Heterogens: ZN, DMS, V14, BCN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4q07A (A:)
mshhwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslril
nnghsfqvefddsqdkavlkggpldgtyrllqfhfhwgsldgqgsehtvdkkkyaaelhl
vhwntkygdvgkalqqpdglavlgiflkvgsakpglqkvvdvldsiktkgksadftnfdp
rgllpesldywtypgslttpplaecvtwivlkepisvsseqvlkfrklnfngegepeelm
vdnwrpaqplknrqikasfk

    Sequence, based on observed residues (ATOM records): (download) 
    >4q07A (A:)
hwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslrilnng
hsfqvefddsqdkavlkggpldgtyrllqfhfhwgsldgqgsehtvdkkkyaaelhlvhw
ntkygdvgkalqqpdglavlgiflkvgsakpglqkvvdvldsiktkgksadftnfdprgl
lpesldywtypgslttpplaecvtwivlkepisvsseqvlkfrklnfngegepeelmvdn
wrpaqplknrqikasfk