PDB entry 4pzt

View 4pzt on RCSB PDB site
Description: Crystal structure of p300 histone acetyltransferase domain in complex with an inhibitor, Acetonyl-Coenzyme A
Class: transferase/transferase inhibitor
Keywords: TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2014-03-31, released 2014-06-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-06-25, with a file datestamp of 2014-06-20.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.161
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone acetyltransferase p300
    Species: Homo sapiens [TaxId:9606]
    Gene: EP300, P300
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q09472 (0-377)
      • engineered mutation (180)
    Domains in SCOPe 2.08: d4pzta_
  • Heterogens: SOP, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4pztA (A:)
kfsakrlpstrlgtflenrvndflrrqnhpesgevtvrvvhasdktvevkpgmkarfvds
gemaesfpyrtkalfafeeidgvdlcffgmhvqeygsdcpppnqrrvyisyldsvhffrp
kclrtavyheiligyleyvkklgyttghiwacppsegddyifhchppdqkipkpkrlqew
fkkmldkavserivhdykdifkqatedrltsakelpyfegdfwpnvleesikeleqeeee
rkreentsnestdvtkgdsknakkknnkktsknksslsrgnkkkpgmpnvsndlsqklya
tmekhkevffvirliagpaanslppivdpdplipcdlmdgrdafltlardkhlefsslrr
aqwstmcmlvelhtqsqd

    Sequence, based on observed residues (ATOM records): (download) 
    >4pztA (A:)
kfsakrlpstrlgtflenrvndflrrqnhpesgevtvrvvhasdktvevkpgmkarfvds
gemaesfpyrtkalfafeeidgvdlcffgmhvqeygsdcpppnqrrvyisyldsvhffrp
kclrtavyheiligyleyvkklgyttghiwacppsegddyifhchppdqkipkpkrlqew
fkkmldkavserivhdykdifkqatedrltsakelpyfegdfwpnvleesikeleqeeee
rkreentsdlsqklyatmekhkevffvirliagpaanslppivdpdplipcdlmdgrdaf
ltlardkhlefsslrraqwstmcmlvelhtqsqd