PDB entry 4pyj

View 4pyj on RCSB PDB site
Description: human apo-COMT, single domain swap
Class: transferase
Keywords: methyltransferase, neurotransmitter degradation, conformational change, catecholamine metabolism, cell membrane, membrane, metal-binding, signal-anchor, enzyme, transferase
Deposited on 2014-03-27, released 2014-06-11
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-08-27, with a file datestamp of 2014-08-22.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.201
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Catechol O-methyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: COMT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4pyja_
  • Heterogens: NA, MG, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4pyjA (A:)
mgdtkeqrilnhvlqhaepgnaqsvleaidtyceqkewamnvgdkkgkivdaviqehqps
vllelgaycgysavrmarllspgarlitieinpdcaaitqrmvdfagvkdkvtlvvgasq
diipqlkkkydvdtldmvfldhwkdrylpdtllleecgllrkgtvlladnvicpgapdfl
ahvrgsscfecthyqsfleyrevvdglekaiykgpgseagp

    Sequence, based on observed residues (ATOM records): (download) 
    >4pyjA (A:)
dtkeqrilnhvlqhaepgnaqsvleaidtyceqkgdkkgkivdaviqehqpsvllelgay
cgysavrmarllspgarlitieinpdcaaitqrmvdfagvkdkvtlvvgasqdiipqlkk
kydvdtldmvfldhwkdrylpdtllleecgllrkgtvlladnvicpgapdflahvrgssc
fecthyqsfleyrevvdglekaiykgpg