PDB entry 4pw8

View 4pw8 on RCSB PDB site
Description: human tryptophan 2,3-dioxygenase
Deposited on 2014-03-19, released 2014-08-06
The last revision was dated 2015-12-16, with a file datestamp of 2015-12-11.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tryptophan 2,3-dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: TDO, TDO2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Tryptophan 2,3-dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: TDO, TDO2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Tryptophan 2,3-dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: TDO, TDO2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Tryptophan 2,3-dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: TDO, TDO2
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Tryptophan 2,3-dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: TDO, TDO2
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Tryptophan 2,3-dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: TDO, TDO2
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Tryptophan 2,3-dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: TDO, TDO2
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Tryptophan 2,3-dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: TDO, TDO2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: CO, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4pw8A (A:)
snapvegseedksqtgvnraskggliygnylhlekvlnaqelqsetkgnkihdehlfiit
hqayelwfkqilweldsvreifqnghvrdernmlkvvsrmhrvsvilkllvqqfsiletm
taldfndfreylspasgfqslqfrllenkigvlqnmrvpynrrhyrdnfkgeenelllks
eqektllelveawlertpglephgfnfwgkleknitrgleeefiriqakeeseekeeqva
efqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfqlltslm
didslmtkwrynhvcmvhrmlgskagtggssgyhylrstvsdrykvfvdlfnlstylipr
hwipkmnptihkf

    Sequence, based on observed residues (ATOM records):
    >4pw8A (A:)
iygnylhlekvlnaqelqsetkgnkihdehlfiithqayelwfkqilweldsvreifqng
hvrdernmlkvvsrmhrvsvilkllvqqfsiletmtaldfndfreylspasgfqslqfrl
lenkigvlqeenelllkseqektllelveawlertpglephgfnfwgkleknitrgleee
firiqakeeseekeeqvaefqkqkevllslfdekrhehllskgerrlsyralqgalmiyf
yreeprfqvpfqlltslmdidslmtkwrynhvcmvhrmlgsrykvfvdlfnlstyliprh
wipkmn

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4pw8B (B:)
snapvegseedksqtgvnraskggliygnylhlekvlnaqelqsetkgnkihdehlfiit
hqayelwfkqilweldsvreifqnghvrdernmlkvvsrmhrvsvilkllvqqfsiletm
taldfndfreylspasgfqslqfrllenkigvlqnmrvpynrrhyrdnfkgeenelllks
eqektllelveawlertpglephgfnfwgkleknitrgleeefiriqakeeseekeeqva
efqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfqlltslm
didslmtkwrynhvcmvhrmlgskagtggssgyhylrstvsdrykvfvdlfnlstylipr
hwipkmnptihkf

    Sequence, based on observed residues (ATOM records):
    >4pw8B (B:)
liygnylhlekvlnaqelqsetkgnkihdehlfiithqayelwfkqilweldsvreifqn
ghvrdernmlkvvsrmhrvsvilkllvqqfsiletmtaldfndfreylspasgfqslqfr
llenkigvlqnfkgeenelllkseqektllelveawlertpglephgfnfwgkleknitr
gleeefirivaefqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprf
qvpfqlltslmdidslmtkwrynhvcmvhrmlykvfvdlfnlstyliprhwipkmn

  • Chain 'C':
    Sequence, based on SEQRES records:
    >4pw8C (C:)
snapvegseedksqtgvnraskggliygnylhlekvlnaqelqsetkgnkihdehlfiit
hqayelwfkqilweldsvreifqnghvrdernmlkvvsrmhrvsvilkllvqqfsiletm
taldfndfreylspasgfqslqfrllenkigvlqnmrvpynrrhyrdnfkgeenelllks
eqektllelveawlertpglephgfnfwgkleknitrgleeefiriqakeeseekeeqva
efqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfqlltslm
didslmtkwrynhvcmvhrmlgskagtggssgyhylrstvsdrykvfvdlfnlstylipr
hwipkmnptihkf

    Sequence, based on observed residues (ATOM records):
    >4pw8C (C:)
iygnylhlekvlnaqelqsetkgnkihdehlfiithqayelwfkqilweldsvreifqng
hvrdernmlkvvsrmhrvsvilkllvqqfsiletmtaldfndfreylsfqslqfrllenk
igvlqnmrvpynreenelllkseqektllelveawlertpglephgfnfwgkleknitrg
leeefiriqakeeseekeeqvaefqkqkevllslfdekrhehllskgerrlsyralqgal
miyfyreeprfqvpfqlltslmdidslmtkwrynhvcmvhrmlgskagrykvfvdlfnls
tyliprhwipkmn

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4pw8D (D:)
snapvegseedksqtgvnraskggliygnylhlekvlnaqelqsetkgnkihdehlfiit
hqayelwfkqilweldsvreifqnghvrdernmlkvvsrmhrvsvilkllvqqfsiletm
taldfndfreylspasgfqslqfrllenkigvlqnmrvpynrrhyrdnfkgeenelllks
eqektllelveawlertpglephgfnfwgkleknitrgleeefiriqakeeseekeeqva
efqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfqlltslm
didslmtkwrynhvcmvhrmlgskagtggssgyhylrstvsdrykvfvdlfnlstylipr
hwipkmnptihkf

    Sequence, based on observed residues (ATOM records):
    >4pw8D (D:)
liygnylhlekvlnaqelqsetkgnkihdehlfiithqayelwfkqilweldsvreifqn
ghvrdernmlkvvsrmhrvsvilkllvqqfsiletmtaldfndfreylspgfqslqfrll
enkigvlenelllkseqektllelveawlertpglephgfnfwgkleknitrgleeefir
aefqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfqlltsl
mdidslmtkwrynhvcmvhrmlgrykvfvdlfnlstyliprhwipkmn

  • Chain 'E':
    Sequence, based on SEQRES records:
    >4pw8E (E:)
snapvegseedksqtgvnraskggliygnylhlekvlnaqelqsetkgnkihdehlfiit
hqayelwfkqilweldsvreifqnghvrdernmlkvvsrmhrvsvilkllvqqfsiletm
taldfndfreylspasgfqslqfrllenkigvlqnmrvpynrrhyrdnfkgeenelllks
eqektllelveawlertpglephgfnfwgkleknitrgleeefiriqakeeseekeeqva
efqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfqlltslm
didslmtkwrynhvcmvhrmlgskagtggssgyhylrstvsdrykvfvdlfnlstylipr
hwipkmnptihkf

    Sequence, based on observed residues (ATOM records):
    >4pw8E (E:)
iygnylhlekvlnaqelqsetkgnkihdehlfiithqayelwfkqilweldsvreifqng
hvrdernmlkvvsrmhrvsvilkllvqqfsiletmtaldfndfreylspasgfqslqfrl
lenkigvlqeenelllkseqektllelveawlertpglephgfnfwgkleknitrgleee
firqvaefqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfq
lltslmdidslmtkwrynhvcmvhrmlgsykvfvdlfnlstyliprhwipkmn

  • Chain 'F':
    Sequence, based on SEQRES records:
    >4pw8F (F:)
snapvegseedksqtgvnraskggliygnylhlekvlnaqelqsetkgnkihdehlfiit
hqayelwfkqilweldsvreifqnghvrdernmlkvvsrmhrvsvilkllvqqfsiletm
taldfndfreylspasgfqslqfrllenkigvlqnmrvpynrrhyrdnfkgeenelllks
eqektllelveawlertpglephgfnfwgkleknitrgleeefiriqakeeseekeeqva
efqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfqlltslm
didslmtkwrynhvcmvhrmlgskagtggssgyhylrstvsdrykvfvdlfnlstylipr
hwipkmnptihkf

    Sequence, based on observed residues (ATOM records):
    >4pw8F (F:)
liygnylhlekvlnaqelqsetkgnkihdehlfiithqayelwfkqilweldsvreifqn
ghvrdernmlkvvsrmhrvsvilkllvqqfsiletmtaldfndfreylspasgfqslqfr
llenkigvlqfkgeenelllkseqektllelveawlertpglephgfnfwgkleknitrg
leeefiriqakeqvaefqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyre
eprfqvpfqlltslmdidslmtkwrynhvcmvhrmlgsrykvfvdlfnlstyliprhwip
kmn

  • Chain 'G':
    Sequence, based on SEQRES records:
    >4pw8G (G:)
snapvegseedksqtgvnraskggliygnylhlekvlnaqelqsetkgnkihdehlfiit
hqayelwfkqilweldsvreifqnghvrdernmlkvvsrmhrvsvilkllvqqfsiletm
taldfndfreylspasgfqslqfrllenkigvlqnmrvpynrrhyrdnfkgeenelllks
eqektllelveawlertpglephgfnfwgkleknitrgleeefiriqakeeseekeeqva
efqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfqlltslm
didslmtkwrynhvcmvhrmlgskagtggssgyhylrstvsdrykvfvdlfnlstylipr
hwipkmnptihkf

    Sequence, based on observed residues (ATOM records):
    >4pw8G (G:)
liygnylhlekvlnaqelqsetkgnkihdehlfiithqayelwfkqilweldsvreifqn
ghvrdernmlkvvsrmhrvsvilkllvqqfsiletmtaldfndfreylspasgfqslqfr
llenkigvlqfkgeenelllkseqektllelveawlertpglephgfnfwgkleknitrg
leeefiriqakeekeeqvaefqkqkevllslfdekrhehllskgerrlsyralqgalmiy
fyreeprfqvpfqlltslmdidslmtkwrynhvcmvhrmrykvfvdlfnlstyliprhwi
pkmn

  • Chain 'H':
    Sequence, based on SEQRES records:
    >4pw8H (H:)
snapvegseedksqtgvnraskggliygnylhlekvlnaqelqsetkgnkihdehlfiit
hqayelwfkqilweldsvreifqnghvrdernmlkvvsrmhrvsvilkllvqqfsiletm
taldfndfreylspasgfqslqfrllenkigvlqnmrvpynrrhyrdnfkgeenelllks
eqektllelveawlertpglephgfnfwgkleknitrgleeefiriqakeeseekeeqva
efqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfqlltslm
didslmtkwrynhvcmvhrmlgskagtggssgyhylrstvsdrykvfvdlfnlstylipr
hwipkmnptihkf

    Sequence, based on observed residues (ATOM records):
    >4pw8H (H:)
liygnylhlekvlnaqelqsetkgnkihdehlfiithqayelwfkqilweldsvreifqn
ghvrdernmlkvvsrmhrvsvilkllvqqfsiletmtaldfndfreylspasgfqslqfr
llenkigvlqeenelllkseqektllelveawlertpglephgfnfwgkleknitrglee
efiriqakeeeeqvaefqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyre
eprfqvpfqlltslmdidslmtkwrynhvcmvhrmlrykvfvdlfnlstyliprhwipkm
n