PDB entry 4pub

View 4pub on RCSB PDB site
Description: Crystal structure of Fab DX-2930
Class: immune system
Keywords: fab, antibody, kallikrein, blood, plasma, plasma kallikrein-mediated edema, acute hereditary angioedema, hae, immune system
Deposited on 2014-03-12, released 2014-07-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-09-10, with a file datestamp of 2014-09-05.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.174
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: dx-2930 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4PUB
    Domains in SCOPe 2.08: d4pubh_
  • Chain 'L':
    Compound: dx-2930 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4PUB (0-End)
    Domains in SCOPe 2.08: d4publ1, d4publ2
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4pubH (H:)
evqllesggglvqpggslrlscaasgftfshyimmwvrqapgkglewvsgiyssggitvy
adsvkgrftisrdnskntlylqmnslraedtavyycayrrigvprrdefdiwgqgtmvtv
ssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlq
ssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >4pubH (H:)
vqllesggglvqpggslrlscaasghyimmwvrqapgkglewvsgiyggitvyadsvkgr
ftisrdnskntlylqmnslraedtavyycayrrirdefdiwgqgtmvtvssastkgpsvf
plapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvv
tvpssslgtqtyicnvnhkpsntkvdkrvepk

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >4pubL (L:)
diqmtqspstlsasvgdrvtitcrasqsisswlawyqqkpgkapklliykastlesgvps
rfsgsgsgteftltisslqpddfatyycqqyntywtfgqgtkveikrtvaapsvfifpps
deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl
skadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >4pubL (L:)
diqmtqspstlsasvgdrvtitcrasqsisswlawyqqkpgkapklliykastlesgvps
rfsgsgsgteftltisslqpddfatyycqqyntywtfgqgtkveikrtvaapsvfifpps
deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl
skadyekhkvyacevthqglsspvtksfnrge