PDB entry 4ptg

View 4ptg on RCSB PDB site
Description: Structure of a carboxamine compound (26) (2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4-METHOXYPYRIMIDINE-5-CARBOXAMIDE) to GSK3b
Class: transferase/transferase inhibitor
Keywords: Serine/threonine kinase, transferase-transferase inhibitor complex
Deposited on 2014-03-10, released 2015-04-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-06-10, with a file datestamp of 2015-06-05.
Experiment type: XRAY
Resolution: 2.36 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glycogen synthase kinase-3 beta
    Species: Homo sapiens [TaxId:9606]
    Gene: GSK3B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4ptga_
  • Chain 'B':
    Compound: Glycogen synthase kinase-3 beta
    Species: Homo sapiens [TaxId:9606]
    Gene: GSK3B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4ptgb_
  • Heterogens: 2WG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ptgA (A:)
mhsshhhhhhssgenlyfqghmsgrprttsfaesckpvqqpsafgsmkvsrdkdgskvtt
vvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfknrelq
imrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlpviyvk
lymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyics
ryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptre
qiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsf
fdelrdpnvklpngrdtpalfnfttqelssnpplatilipphariqaaastptnataasd
antgdrgqtnnaasasasnst

    Sequence, based on observed residues (ATOM records): (download) 
    >4ptgA (A:)
kvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfkn
relqimrkldhcnivrlryffysevylnlvldyvpetvyrvarhysrakqtlpviyvkly
myqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyicsry
yrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptreqi
remfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsffdelrdpnvk
lpngrdtpalfnfttqelssnpplatilippha

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ptgB (B:)
mhsshhhhhhssgenlyfqghmsgrprttsfaesckpvqqpsafgsmkvsrdkdgskvtt
vvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfknrelq
imrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlpviyvk
lymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyics
ryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptre
qiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsf
fdelrdpnvklpngrdtpalfnfttqelssnpplatilipphariqaaastptnataasd
antgdrgqtnnaasasasnst

    Sequence, based on observed residues (ATOM records): (download) 
    >4ptgB (B:)
vttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfknr
elqimrkldhcnivrlryffyssdevylnlvldyvpetvyrvarhysrakqtlpviyvkl
ymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyicsr
yyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptreq
iremahpwtkvfrprtppeaialcsrlleytptarltpleacahsffdelrdpnvklpng
rdtpalfnfttqelssnpplatilipphariq