PDB entry 4pte

View 4pte on RCSB PDB site
Description: Structure of a carvoxamide compound (15) (N-[4-(ISOQUINOLIN-7-YL)PYRIDIN-2-YL]CYCLOPROPANECARBOXAMIDE) to GSK3b
Class: transferase/transferase inhibitor
Keywords: Serine/threonine kinase, transferase-transferase inhibitor complex
Deposited on 2014-03-10, released 2015-04-08
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-06-10, with a file datestamp of 2015-06-05.
Experiment type: XRAY
Resolution: 2.03 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glycogen synthase kinase-3 beta
    Species: Homo sapiens [TaxId:9606]
    Gene: GSK3B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4ptea_
  • Chain 'B':
    Compound: Glycogen synthase kinase-3 beta
    Species: Homo sapiens [TaxId:9606]
    Gene: GSK3B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4pteb_
  • Heterogens: 2WF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4pteA (A:)
mhsshhhhhhssgenlyfqghmsgrprttsfaesckpvqqpsafgsmkvsrdkdgskvtt
vvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfknrelq
imrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlpviyvk
lymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyics
ryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptre
qiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsf
fdelrdpnvklpngrdtpalfnfttqelssnpplatilipphariqaaastptnataasd
antgdrgqtnnaasasasnst

    Sequence, based on observed residues (ATOM records): (download) 
    >4pteA (A:)
kvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdfknre
lqimrkldhcnivrlryffyssdevylnlvldyvpetvyrvarhysrakqtlpviyvkly
myqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyicsry
yrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptreqi
remnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsffd
elrdpnvklpngrdtpalfnfttqelssnpplatilippha

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4pteB (B:)
mhsshhhhhhssgenlyfqghmsgrprttsfaesckpvqqpsafgsmkvsrdkdgskvtt
vvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfknrelq
imrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlpviyvk
lymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyics
ryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptre
qiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsf
fdelrdpnvklpngrdtpalfnfttqelssnpplatilipphariqaaastptnataasd
antgdrgqtnnaasasasnst

    Sequence, based on observed residues (ATOM records): (download) 
    >4pteB (B:)
kvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfkn
relqimrkldhcnivrlryffyssgeevylnlvldyvpetvyrvarhysrakqtlpviyv
klymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyic
sryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptr
eqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahs
ffdelrdpnvklpngrdtpalfnfttqelssnpplatilipphariq