PDB entry 4ptc

View 4ptc on RCSB PDB site
Description: Structure of a carboxamide compound (3) (2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4-OXO-4H-1LAMBDA~4~,3-THIAZOLE-5-CARBOXAMIDE) to GSK3b
Class: transferase/transferase inhibitor
Keywords: Serine/threonine kinase, transferase-transferase inhibitor complex
Deposited on 2014-03-10, released 2015-04-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-02-19, with a file datestamp of 2020-02-14.
Experiment type: XRAY
Resolution: 2.71 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glycogen synthase kinase-3 beta
    Species: Homo sapiens [TaxId:9606]
    Gene: GSK3B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4ptca_
  • Chain 'B':
    Compound: Glycogen synthase kinase-3 beta
    Species: Homo sapiens [TaxId:9606]
    Gene: GSK3B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4ptcb_
  • Heterogens: 2WE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ptcA (A:)
mhsshhhhhhssgenlyfqghmsgrprttsfaesckpvqqpsafgsmkvsrdkdgskvtt
vvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfknrelq
imrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlpviyvk
lymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyics
ryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptre
qiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsf
fdelrdpnvklpngrdtpalfnfttqelssnpplatilipphariqaaastptnataasd
antgdrgqtnnaasasasnst

    Sequence, based on observed residues (ATOM records): (download) 
    >4ptcA (A:)
kvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfkn
relqimrkldhcnivrlryffyssdevylnlvldyvpetvyrvarhysrakqtlpviyvk
lymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyics
ryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptre
qiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsf
fdelrdpnvklpngrdtpalfnfttqelssnpplatilipph

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ptcB (B:)
mhsshhhhhhssgenlyfqghmsgrprttsfaesckpvqqpsafgsmkvsrdkdgskvtt
vvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfknrelq
imrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlpviyvk
lymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyics
ryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptre
qiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsf
fdelrdpnvklpngrdtpalfnfttqelssnpplatilipphariqaaastptnataasd
antgdrgqtnnaasasasnst

    Sequence, based on observed residues (ATOM records): (download) 
    >4ptcB (B:)
skvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfk
nrelqimrkldhcnivrlryffyssdevylnlvldyvpetvyrvarhysrakqtlpviyv
klymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyic
sryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptr
eqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahs
ffdelrdpnvklpngrdtpalfnfttqelssnpplatilipphariq