PDB entry 4ppx

View 4ppx on RCSB PDB site
Description: DNA Polymerase Beta E295K with Spiroiminodihydantoin in Templating Position
Class: transferase, lyase/DNA
Keywords: DNA Polymerase, DNA complex, TRANSFERASE, LYASE-DNA complex
Deposited on 2014-02-27, released 2014-04-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.08 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA polymerase beta
    Species: Homo sapiens [TaxId:9606]
    Gene: POLB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06746 (Start-334)
      • engineered mutation (294)
    Domains in SCOPe 2.08: d4ppxa1, d4ppxa2, d4ppxa3
  • Chain 'D':
    Compound: 5'-d(*gp*tp*cp*gp*g)-3'
  • Chain 'P':
    Compound: 5'-d(*gp*cp*tp*gp*ap*tp*gp*cp*gp*c)-3'
  • Chain 'T':
    Compound: 5'-d(*cp*cp*gp*ap*cp*(sdh)p*gp*cp*gp*cp*ap*tp*cp*ap*gp*c)-3'
  • Heterogens: NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ppxA (A:)
mskrkapqetlnggitdmltelanfeknvsqaihkynayrkaasviakyphkiksgaeak
klpgvgtkiaekideflatgklrklekirqddtsssinfltrvsgigpsaarkfvdegik
tledlrknedklnhhqriglkyfgdfekripreemlqmqdivlnevkkvdseyiatvcgs
frrgaessgdmdvllthpsftsestkqpkllhqvveqlqkvhfitdtlskgetkfmgvcq
lpskndekeyphrridirlipkdqyycgvlyftgsdifnknmrahalekgftinkytirp
lgvtgvageplpvdsekdifdyiqwkyrepkdrse

    Sequence, based on observed residues (ATOM records): (download) 
    >4ppxA (A:)
etlnggitdmltelanfeknvsqaihkynayrkaasviakyphkiksgaeakklpgvgtk
iaekideflatgklrklekirqddtsssinfltrvsgigpsaarkfvdegiktledlrkn
edklnhhqriglkyfgdfekripreemlqmqdivlnevkkvdseyiatvcgsfrrgaess
gdmdvllthpsftseskllhqvveqlqkvhfitdtlskgetkfmgvcqlpskeyphrrid
irlipkdqyycgvlyftgsdifnknmrahalekgftinkytirplageplpvdsekdifd
yiqwkyrepkdrse

  • Chain 'D':
    No sequence available.

  • Chain 'P':
    No sequence available.

  • Chain 'T':
    No sequence available.