PDB entry 4pod

View 4pod on RCSB PDB site
Description: Structure of Triosephosphate Isomerase I170V mutant human enzyme.
Class: Isomerase
Keywords: TIM Alpha/Beta Barrel, TIM Barrel, Isomerase, Glycolytic
Deposited on 2014-02-25, released 2015-01-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-01-14, with a file datestamp of 2015-01-09.
Experiment type: XRAY
Resolution: 1.99 Å
R-factor: 0.172
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: triosephosphate isomerase
    Species: Homo sapiens [TaxId:9606]
    Gene: TPI, TPI1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60174 (Start-253)
      • engineered mutation (175)
    Domains in SCOPe 2.08: d4poda_
  • Chain 'B':
    Compound: triosephosphate isomerase
    Species: Homo sapiens [TaxId:9606]
    Gene: TPI, TPI1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60174
      • engineered mutation (175)
    Domains in SCOPe 2.08: d4podb_
  • Heterogens: K, NA, PO4, BR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4podA (A:)
gdithmapsrkffvggnwkmngrkqslgeligtlnaakvpadtevvcapptayidfarqk
ldpkiavaaqncykvtngaftgeispgmikdcgatwvvlghserrhvfgesdeligqkva
halaeglgviacigekldereagitekvvfeqtkviadnvkdwskvvlayepvwavgtgk
tatpqqaqevheklrgwlksnvsdavaqstriiyggsvtgatckelasqpdvdgflvgga
slkpefvdiinakq

    Sequence, based on observed residues (ATOM records): (download) 
    >4podA (A:)
rkffvggnwkmngrkqslgeligtlnaakvpadtevvcapptayidfarqkldpkiavaa
qncykvtngaftgeispgmikdcgatwvvlghserrhvfgesdeligqkvahalaeglgv
iacigekldereagitekvvfeqtkviadnvkdwskvvlayepvwavgtgktatpqqaqe
vheklrgwlksnvsdavaqstriiyggsvtgatckelasqpdvdgflvggaslkpefvdi
inakq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4podB (B:)
gdithmapsrkffvggnwkmngrkqslgeligtlnaakvpadtevvcapptayidfarqk
ldpkiavaaqncykvtngaftgeispgmikdcgatwvvlghserrhvfgesdeligqkva
halaeglgviacigekldereagitekvvfeqtkviadnvkdwskvvlayepvwavgtgk
tatpqqaqevheklrgwlksnvsdavaqstriiyggsvtgatckelasqpdvdgflvgga
slkpefvdiinakq

    Sequence, based on observed residues (ATOM records): (download) 
    >4podB (B:)
srkffvggnwkmngrkqslgeligtlnaakvpadtevvcapptayidfarqkldpkiava
aqncykvtngaftgeispgmikdcgatwvvlghserrhvfgesdeligqkvahalaeglg
viacigekldereagitekvvfeqtkviadnvkdwskvvlayepvwavgtgktatpqqaq
evheklrgwlksnvsdavaqstriiyggsvtgatckelasqpdvdgflvggaslkpefvd
iinak