PDB entry 4pnk

View 4pnk on RCSB PDB site
Description: G protein-coupled receptor kinase 2 in complex with GSK180736A
Class: Transferase/Transferase inhibitor
Keywords: PROTEIN KINASE, HYDROLASE, ATP BINDING, PHOSPHORYLATION, PERIPHERAL MEMBRANE PROTEIN, Transferase-Transferase inhibitor complex
Deposited on 2014-05-23, released 2014-10-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-06, with a file datestamp of 2017-09-01.
Experiment type: XRAY
Resolution: 2.56 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: ADRBK1, BARK, BARK1, GRK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4pnka1, d4pnka2, d4pnka3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4pnkb_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Bos taurus [TaxId:9913]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63212
      • engineered mutation (67)
    Domains in SCOPe 2.07: d4pnkg_
  • Heterogens: KZQ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4pnkA (A:)
    madleavladvsylmamekskatpaaraskkillpepsirsvmqkyledrgevtfekifs
    qklgyllfrdfclnhleearplvefyeeikkyekleteeervarsreifdsyimkellac
    shpfsksatehvqghlgkkqvppdlfqpyieeicqnlrgdvfqkfiesdkftrfcqwknv
    elnihltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalner
    imlslvstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaae
    iilglehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymape
    vlqkgvaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspe
    lrsllegllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgevnaa
    dafdigsfdeedtkgiklldsdqelyrnfpltiserwqqevaetvfdtinaetdrleark
    kaknkqlgheedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlewrgegeapqsl
    ltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrdayreaqqlvqr
    vpkmknkprspvvelskvplvqrgsangl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4pnkA (A:)
    kkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyeei
    kkyekleteeervarsreifdsyimkellacshpfsksatehvqghlgkkqvppdlfqpy
    ieeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygcr
    kadtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdklsf
    ildlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldehg
    hvrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrghs
    pfrqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevke
    spffrsldwqmvflqkyppplipprevnatkgiklldsdqelyrnfpltiserwqqevae
    tvfdtinaetdrlearkkaknkqlgheedyalgkdcimhgymskmgnpfltqwqrryfyl
    fpnrlewrgegeapqslltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqw
    kkelrdayreaqqlvqrvpkmknkp
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4pnkB (B:)
    mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
    mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
    csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
    tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
    fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
    kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

    Sequence, based on observed residues (ATOM records): (download)
    >4pnkB (B:)
    seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
    hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
    siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
    ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
    atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
    adragvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >4pnkG (G:)
    masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
    frekkffsail
    

    Sequence, based on observed residues (ATOM records): (download)
    >4pnkG (G:)
    asiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrekkf
    fs