PDB entry 4pmt

View 4pmt on RCSB PDB site
Description: The structure of TrkA kinase bound to the inhibitor N~4~-(4-morpholin-4-ylphenyl)-N~6~-(pyridin-3-ylmethyl)pyrido[3,2-d]pyrimidine-4,6-diamine
Class: Transferase/Transferase inhibitor
Keywords: kinase, Transferase-Transferase inhibitor complex
Deposited on 2014-05-22, released 2014-06-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-02-25, with a file datestamp of 2015-02-20.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.186
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: high affinity nerve growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NTRK1, MTC, TRK, TRKA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04629 (0-286)
      • expression tag (287-290)
    Domains in SCOPe 2.08: d4pmta1, d4pmta2
  • Heterogens: 31Y, CL, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4pmtA (A:)
cvhhikrrdivlkwelgegafgkvflaechnllpeqdkmlvavkalkeasesarqdfqre
aelltmlqhqhivrffgvctegrpllmvfeymrhgdlnrflrshgpdakllaggedvapg
plglgqllavasqvaagmvylaglhfvhrdlatrnclvgqglvvkigdfgmsrdiystdy
yrvggrtmlpirwmppesilyrkfttesdvwsfgvvlweiftygkqpwyqlsnteaidci
tqgrelerpracppevyaimrgcwqrepqqrhsikdvharlqalaqahhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4pmtA (A:)
cvhhikrrdivlkwelgegafgkvflaechnldkmlvavkaldfqreaelltmlqhqhiv
rffgvctegrpllmvfeymrhgdlnrflrshgpdakllaggedvapgplglgqllavasq
vaagmvylaglhfvhrdlatrnclvgqglvvkigdfsrdiystdyyrvtmlpirwmppes
ilyrkfttesdvwsfgvvlweiftygkqpwyqlsnteaidcitqgrelerpracppevya
imrgcwqrepqqrhsikdvharlqalaqahhhh