PDB entry 4ply

View 4ply on RCSB PDB site
Description: crystal structure of ancestral apicomplexan malate dehydrogenase with malate.
Deposited on 2014-05-19, released 2014-07-02
The last revision was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: malate dehydrogenase
    Species: Apicomplexa [TaxId:5794]
    Database cross-references and differences (RAF-indexed):
    • PDB 4PLY
  • Chain 'B':
    Compound: malate dehydrogenase
    Species: Apicomplexa [TaxId:5794]
    Database cross-references and differences (RAF-indexed):
    • PDB 4PLY
  • Chain 'C':
    Compound: malate dehydrogenase
    Species: Apicomplexa [TaxId:5794]
    Database cross-references and differences (RAF-indexed):
    • PDB 4PLY
  • Chain 'D':
    Compound: malate dehydrogenase
    Species: Apicomplexa [TaxId:5794]
    Database cross-references and differences (RAF-indexed):
    • PDB 4PLY
  • Chain 'E':
    Compound: malate dehydrogenase
    Species: Apicomplexa [TaxId:5794]
    Database cross-references and differences (RAF-indexed):
    • PDB 4PLY
  • Chain 'F':
    Compound: malate dehydrogenase
    Species: Apicomplexa [TaxId:5794]
    Database cross-references and differences (RAF-indexed):
    • PDB 4PLY
  • Chain 'G':
    Compound: malate dehydrogenase
    Species: Apicomplexa [TaxId:5794]
    Database cross-references and differences (RAF-indexed):
    • PDB 4PLY
  • Chain 'H':
    Compound: malate dehydrogenase
    Species: Apicomplexa [TaxId:5794]
    Database cross-references and differences (RAF-indexed):
    • PDB 4PLY
  • Heterogens: NAI, PYR, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4plyA (A:)
    mtqrkkisligagniggtlahliaqkelgdvvlfdivegmpqgkaldishsspimgsnvk
    itgtnnyedikgsdvviitagiprkpgksdkewsrddllsvnakimkdvaenikkycpna
    fvivvtnpldvmvyvlhkysglphnkvcgmagvldssrfryflaeklnvspndvqamvig
    ghgdtmvpltryctvggipltefikqgwitqeeideivertrnaggeivnllktgsayfa
    paasaiemaesylkdkkrilpcsaylegqygvkdlfvgvpviigkngvekiielelteee
    qemfdksvesvrelvetvkklnalehhhhhh
    

    Sequence, based on observed residues (ATOM records):
    >4plyA (A:)
    qrkkisligagniggtlahliaqkelgdvvlfdivegmpqgkaldishsspimgsnvkit
    gtnnyedikgsdvviitagiprkpgksdkewsrddllsvnakimkdvaenikkycpnafv
    ivvtnpldvmvyvlhkysglphnkvcgmagvldssrfryflaeklnvspndvqamviggh
    gdtmvpltryctvggipltefikqgwitqeeideivertrnaggeivnllktgsayfapa
    asaiemaesylkdkkrilpcsaylegqygvkdlfvgvpviigkngvekiielelteeeqe
    mfdksvesvrelvetvkk
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4plyB (B:)
    mtqrkkisligagniggtlahliaqkelgdvvlfdivegmpqgkaldishsspimgsnvk
    itgtnnyedikgsdvviitagiprkpgksdkewsrddllsvnakimkdvaenikkycpna
    fvivvtnpldvmvyvlhkysglphnkvcgmagvldssrfryflaeklnvspndvqamvig
    ghgdtmvpltryctvggipltefikqgwitqeeideivertrnaggeivnllktgsayfa
    paasaiemaesylkdkkrilpcsaylegqygvkdlfvgvpviigkngvekiielelteee
    qemfdksvesvrelvetvkklnalehhhhhh
    

    Sequence, based on observed residues (ATOM records):
    >4plyB (B:)
    qrkkisligagniggtlahliaqkelgdvvlfdivegmpqgkaldishsspimgsnvkit
    gtnnyedikgsdvviitagiprkpgksdkewsrddllsvnakimkdvaenikkycpnafv
    ivvtnpldvmvyvlhkysglphnkvcgmagvldssrfryflaeklnvspndvqamviggh
    gdtmvpltryctvggipltefikqgwitqeeideivertrnaggeivnllktgsayfapa
    asaiemaesylkdkkrilpcsaylegqygvkdlfvgvpviigkngvekiielelteeeqe
    mfdksvesvrelvetvkk
    

  • Chain 'C':
    Sequence, based on SEQRES records:
    >4plyC (C:)
    mtqrkkisligagniggtlahliaqkelgdvvlfdivegmpqgkaldishsspimgsnvk
    itgtnnyedikgsdvviitagiprkpgksdkewsrddllsvnakimkdvaenikkycpna
    fvivvtnpldvmvyvlhkysglphnkvcgmagvldssrfryflaeklnvspndvqamvig
    ghgdtmvpltryctvggipltefikqgwitqeeideivertrnaggeivnllktgsayfa
    paasaiemaesylkdkkrilpcsaylegqygvkdlfvgvpviigkngvekiielelteee
    qemfdksvesvrelvetvkklnalehhhhhh
    

    Sequence, based on observed residues (ATOM records):
    >4plyC (C:)
    qrkkisligagniggtlahliaqkelgdvvlfdivegmpqgkaldishsspimgsnvkit
    gtnnyedikgsdvviitagllsvnakimkdvaenikkycpnafvivvtnpldvmvyvlhk
    ysglphnkvcgmagvldssrfryflaeklnvspndvqamvigghgdtmvpltryctvggi
    pltefikqgwitqeeideivertrnaggeivnllktgsayfapaasaiemaesylkdkkr
    ilpcsaylegqygvkdlfvgvpviigkngvekiielelteeeqemfdksvesvrelvetv
    kkl
    

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4plyD (D:)
    mtqrkkisligagniggtlahliaqkelgdvvlfdivegmpqgkaldishsspimgsnvk
    itgtnnyedikgsdvviitagiprkpgksdkewsrddllsvnakimkdvaenikkycpna
    fvivvtnpldvmvyvlhkysglphnkvcgmagvldssrfryflaeklnvspndvqamvig
    ghgdtmvpltryctvggipltefikqgwitqeeideivertrnaggeivnllktgsayfa
    paasaiemaesylkdkkrilpcsaylegqygvkdlfvgvpviigkngvekiielelteee
    qemfdksvesvrelvetvkklnalehhhhhh
    

    Sequence, based on observed residues (ATOM records):
    >4plyD (D:)
    qrkkisligagniggtlahliaqkelgdvvlfdivegmpqgkaldishsspimgsnvkit
    gtnnyedikgsdvviitagdllsvnakimkdvaenikkycpnafvivvtnpldvmvyvlh
    kysglphnkvcgmagvldssrfryflaeklnvspndvqamvigghgdtmvpltryctvgg
    ipltefikqgwitqeeideivertrnaggeivnllktgsayfapaasaiemaesylkdkk
    rilpcsaylegqygvkdlfvgvpviigkngvekiielelteeeqemfdksvesvrelvet
    vkk
    

  • Chain 'E':
    Sequence, based on SEQRES records:
    >4plyE (E:)
    mtqrkkisligagniggtlahliaqkelgdvvlfdivegmpqgkaldishsspimgsnvk
    itgtnnyedikgsdvviitagiprkpgksdkewsrddllsvnakimkdvaenikkycpna
    fvivvtnpldvmvyvlhkysglphnkvcgmagvldssrfryflaeklnvspndvqamvig
    ghgdtmvpltryctvggipltefikqgwitqeeideivertrnaggeivnllktgsayfa
    paasaiemaesylkdkkrilpcsaylegqygvkdlfvgvpviigkngvekiielelteee
    qemfdksvesvrelvetvkklnalehhhhhh
    

    Sequence, based on observed residues (ATOM records):
    >4plyE (E:)
    qrkkisligagniggtlahliaqkelgdvvlfdivegmpqgkaldishsspimgsnvkit
    gtnnyedikgsdvviitagiprkpgksdkewsrddllsvnakimkdvaenikkycpnafv
    ivvtnpldvmvyvlhkysglphnkvcgmagvldssrfryflaeklnvspndvqamviggh
    gdtmvpltryctvggipltefikqgwitqeeideivertrnaggeivnllktgsayfapa
    asaiemaesylkdkkrilpcsaylegqygvkdlfvgvpviigkngvekiielelteeeqe
    mfdksvesvrelvetvkk
    

  • Chain 'F':
    Sequence, based on SEQRES records:
    >4plyF (F:)
    mtqrkkisligagniggtlahliaqkelgdvvlfdivegmpqgkaldishsspimgsnvk
    itgtnnyedikgsdvviitagiprkpgksdkewsrddllsvnakimkdvaenikkycpna
    fvivvtnpldvmvyvlhkysglphnkvcgmagvldssrfryflaeklnvspndvqamvig
    ghgdtmvpltryctvggipltefikqgwitqeeideivertrnaggeivnllktgsayfa
    paasaiemaesylkdkkrilpcsaylegqygvkdlfvgvpviigkngvekiielelteee
    qemfdksvesvrelvetvkklnalehhhhhh
    

    Sequence, based on observed residues (ATOM records):
    >4plyF (F:)
    qrkkisligagniggtlahliaqkelgdvvlfdivegmpqgkaldishsspimgsnvkit
    gtnnyedikgsdvviitagiprkpgksdkewsrddllsvnakimkdvaenikkycpnafv
    ivvtnpldvmvyvlhkysglphnkvcgmagvldssrfryflaeklnvspndvqamviggh
    gdtmvpltryctvggipltefikqgwitqeeideivertrnaggeivnllktgsayfapa
    asaiemaesylkdkkrilpcsaylegqygvkdlfvgvpviigkngvekiielelteeeqe
    mfdksvesvrelvetvkk
    

  • Chain 'G':
    Sequence, based on SEQRES records:
    >4plyG (G:)
    mtqrkkisligagniggtlahliaqkelgdvvlfdivegmpqgkaldishsspimgsnvk
    itgtnnyedikgsdvviitagiprkpgksdkewsrddllsvnakimkdvaenikkycpna
    fvivvtnpldvmvyvlhkysglphnkvcgmagvldssrfryflaeklnvspndvqamvig
    ghgdtmvpltryctvggipltefikqgwitqeeideivertrnaggeivnllktgsayfa
    paasaiemaesylkdkkrilpcsaylegqygvkdlfvgvpviigkngvekiielelteee
    qemfdksvesvrelvetvkklnalehhhhhh
    

    Sequence, based on observed residues (ATOM records):
    >4plyG (G:)
    qrkkisligagniggtlahliaqkelgdvvlfdivegmpqgkaldishsspimgsnvkit
    gtnnyedikgsdvviitagllsvnakimkdvaenikkycpnafvivvtnpldvmvyvlhk
    ysglphnkvcgmagvldssrfryflaeklnvspndvqamvigghgdtmvpltryctvggi
    pltefikqgwitqeeideivertrnaggeivnllktgsayfapaasaiemaesylkdkkr
    ilpcsaylegqygvkdlfvgvpviigkngvekiielelteeeqemfdksvesvrelvetv
    kkl
    

  • Chain 'H':
    Sequence, based on SEQRES records:
    >4plyH (H:)
    mtqrkkisligagniggtlahliaqkelgdvvlfdivegmpqgkaldishsspimgsnvk
    itgtnnyedikgsdvviitagiprkpgksdkewsrddllsvnakimkdvaenikkycpna
    fvivvtnpldvmvyvlhkysglphnkvcgmagvldssrfryflaeklnvspndvqamvig
    ghgdtmvpltryctvggipltefikqgwitqeeideivertrnaggeivnllktgsayfa
    paasaiemaesylkdkkrilpcsaylegqygvkdlfvgvpviigkngvekiielelteee
    qemfdksvesvrelvetvkklnalehhhhhh
    

    Sequence, based on observed residues (ATOM records):
    >4plyH (H:)
    qrkkisligagniggtlahliaqkelgdvvlfdivegmpqgkaldishsspimgsnvkit
    gtnnyedikgsdvviitagdllsvnakimkdvaenikkycpnafvivvtnpldvmvyvlh
    kysglphnkvcgmagvldssrfryflaeklnvspndvqamvigghgdtmvpltryctvgg
    ipltefikqgwitqeeideivertrnaggeivnllktgsayfapaasaiemaesylkdkk
    rilpcsaylegqygvkdlfvgvpviigkngvekiielelteeeqemfdksvesvrelvet
    vkk