PDB entry 4pl5

View 4pl5 on RCSB PDB site
Description: crystal structure of murine ire1 in complex with oicr573 inhibitor
Deposited on 2014-05-16, released 2014-09-03
The last revision was dated 2020-01-08, with a file datestamp of 2020-01-03.
Experiment type: XRAY
Resolution: 3.4 Å
R-factor: N/A
AEROSPACI score: 0.08 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase/endoribonuclease IRE1
    Species: Mus musculus [TaxId:10090]
    Gene: ERN1, IRE1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9EQY0
      • engineered mutation (229)
  • Chain 'B':
    Compound: Serine/threonine-protein kinase/endoribonuclease IRE1
    Species: Mus musculus [TaxId:10090]
    Gene: ERN1, IRE1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9EQY0
      • engineered mutation (229)
  • Chain 'C':
    Compound: Serine/threonine-protein kinase/endoribonuclease IRE1
    Species: Mus musculus [TaxId:10090]
    Gene: ERN1, IRE1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9EQY0
      • engineered mutation (229)
  • Chain 'D':
    Compound: Serine/threonine-protein kinase/endoribonuclease IRE1
    Species: Mus musculus [TaxId:10090]
    Gene: ERN1, IRE1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9EQY0
      • engineered mutation (229)
  • Heterogens: ADP, MG, 31L, PEU

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4pl5A (A:)
gamdpefpsleqddedeetrmvivgkisfcpkdvlghgaegtivykgmfdnrdvavkril
pecfsfadrevqllresdehpnviryfctekdrqfqyiaielcaatlqeyveqkdfahlg
lepitllhqttsglahlhslnivhrdlkphnillsmpnahgrikamisdfglckklavgr
hsfsrrsgvpgtegwiapemlsedckdnptytvdifsagcvfyyvisegyhpfgkslqrq
anillgacnldcfhsdkhedviareliekmiamdpqqrpsakhvlkhpffwslekqlqff
qdvsdriekealdgpivrqlerggravvkmdwrenitvplqtdlrkfrtykggsvrdllr
amrnkkhhyrelpvevqetlgsipddfvryftsrfphllshtyqamelcrherlfqtyyw
heptepqppvipyal

    Sequence, based on observed residues (ATOM records):
    >4pl5A (A:)
rmvivgkisfcpkdvlghgaegtivykgmfdnrdvavkrilpecfsfadrevqllresde
hpnviryfctekdrqfqyiaielcaatlqeyveqkdfahlglepitllhqttsglahlhs
lnivhrdlkphnillsmpnahgrikamisdfglckklvpgtegwiapemlseptytvdif
sagcvfyyvisegyhpfgkslqrqanillgacnldcfhsdkhedviareliekmiamdpq
qrpsakhvlkhpffwslekqlqffqdvsdriekealdgpivrqlerggravvkmdwreni
tvplqtdlrkfrtykggsvrdllramrnkkhhyrelpvevqetlgsipddfvryftsrfp
hllshtyqamelcrherlfqtyywhe

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4pl5B (B:)
gamdpefpsleqddedeetrmvivgkisfcpkdvlghgaegtivykgmfdnrdvavkril
pecfsfadrevqllresdehpnviryfctekdrqfqyiaielcaatlqeyveqkdfahlg
lepitllhqttsglahlhslnivhrdlkphnillsmpnahgrikamisdfglckklavgr
hsfsrrsgvpgtegwiapemlsedckdnptytvdifsagcvfyyvisegyhpfgkslqrq
anillgacnldcfhsdkhedviareliekmiamdpqqrpsakhvlkhpffwslekqlqff
qdvsdriekealdgpivrqlerggravvkmdwrenitvplqtdlrkfrtykggsvrdllr
amrnkkhhyrelpvevqetlgsipddfvryftsrfphllshtyqamelcrherlfqtyyw
heptepqppvipyal

    Sequence, based on observed residues (ATOM records):
    >4pl5B (B:)
rmvivgkisfcpkdvlghgaegtivykgmfdnrdvavkrilpecfsfadrevqllresde
hpnviryfctekdrqfqyiaielcaatlqeyveqkdfahlglepitllhqttsglahlhs
lnivhrdlkphnillsmpnahgrikamisdfglckkvpgtegwiapemlsptytvdifsa
gcvfyyvisegyhpfgkslqrqanillgacnldcfhsdkhedviareliekmiamdpqqr
psakhvlkhpffwslekqlqffqdvsdriekealdgpivrqlerggravvkmdwrenitv
plqtdlrkfrtykggsvrdllramrnkkhhyrelpvevqetlgsipddfvryftsrfphl
lshtyqamelcrherlfqtyywh

  • Chain 'C':
    Sequence, based on SEQRES records:
    >4pl5C (C:)
gamdpefpsleqddedeetrmvivgkisfcpkdvlghgaegtivykgmfdnrdvavkril
pecfsfadrevqllresdehpnviryfctekdrqfqyiaielcaatlqeyveqkdfahlg
lepitllhqttsglahlhslnivhrdlkphnillsmpnahgrikamisdfglckklavgr
hsfsrrsgvpgtegwiapemlsedckdnptytvdifsagcvfyyvisegyhpfgkslqrq
anillgacnldcfhsdkhedviareliekmiamdpqqrpsakhvlkhpffwslekqlqff
qdvsdriekealdgpivrqlerggravvkmdwrenitvplqtdlrkfrtykggsvrdllr
amrnkkhhyrelpvevqetlgsipddfvryftsrfphllshtyqamelcrherlfqtyyw
heptepqppvipyal

    Sequence, based on observed residues (ATOM records):
    >4pl5C (C:)
rmvivgkisfcpkdvlghgaegtivykgmfdnrdvavkrilpecfsfadrevqllresde
hpnviryfctekdrqfqyiaielcaatlqeyveqkdfahlglepitllhqttsglahlhs
lnivhrdlkphnillsmpnahgrikamisdfglckklavpgtegwiapemlsnptytvdi
fsagcvfyyvisegyhpfgkslqrqanillgacnldcfhsdkhedviareliekmiamdp
qqrpsakhvlkhpffwslekqlqffqdvsdriekealdgpivrqlerggravvkmdwren
itvplqtdlrkfrtykggsvrdllramrnkkhhyrelpvevqetlgsipddfvryftsrf
phllshtyqamelcrherlfqtyywh

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4pl5D (D:)
gamdpefpsleqddedeetrmvivgkisfcpkdvlghgaegtivykgmfdnrdvavkril
pecfsfadrevqllresdehpnviryfctekdrqfqyiaielcaatlqeyveqkdfahlg
lepitllhqttsglahlhslnivhrdlkphnillsmpnahgrikamisdfglckklavgr
hsfsrrsgvpgtegwiapemlsedckdnptytvdifsagcvfyyvisegyhpfgkslqrq
anillgacnldcfhsdkhedviareliekmiamdpqqrpsakhvlkhpffwslekqlqff
qdvsdriekealdgpivrqlerggravvkmdwrenitvplqtdlrkfrtykggsvrdllr
amrnkkhhyrelpvevqetlgsipddfvryftsrfphllshtyqamelcrherlfqtyyw
heptepqppvipyal

    Sequence, based on observed residues (ATOM records):
    >4pl5D (D:)
trmvivgkisfcpkdvlghgaegtivykgmfdnrdvavkrilpecfsfadrevqllresd
ehpnviryfctekdrqfqyiaielcaatlqeyveqkdfahlglepitllhqttsglahlh
slnivhrdlkphnillsmpnahgrikamisdfglckklvpgtegwiapemlsptytvdif
sagcvfyyvisegyhpfgkslqrqanillgacnldcfhsdkhedviareliekmiamdpq
qrpsakhvlkhpffwslekqlqffqdvsdriekealdgpivrqlerggravvkmdwreni
tvplqtdlrkfrtykggsvrdllramrnkkhhyrelpvevqetlgsipddfvryftsrfp
hllshtyqamelcrherlfqtyywh