PDB entry 4piv

View 4piv on RCSB PDB site
Description: Human Fatty Acid Synthase Psi/KR Tri-Domain with NADPH and GSK2194069
Class: transferase/transferase inhibitor
Keywords: fatty acid synthase, human FAS, keto-reductase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2014-05-09, released 2014-07-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-17, with a file datestamp of 2019-07-12.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fatty acid synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FASN, FAS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49327 (1-End)
      • initiating methionine (0)
    • Uniprot P49327 (416-End)
    Domains in SCOPe 2.08: d4piva1, d4piva2, d4piva3
  • Chain 'B':
    Compound: fatty acid synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FASN, FAS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4pivb1, d4pivb2, d4pivb3
  • Heterogens: CAC, NDP, SO4, 2W4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4pivA (A:)
mqvpilekfcftphteegclseraalqeelqlckglvqalqtkvtqqglkmvvpgldgaq
iprdpsqqelprllsaacrlqlngnlqlelaqvlaqerpklpedpllsglldspalkacl
dtavenmpslkmkvvevlaghghlysripgllsphpllqlsytatdrhpqaleaaqaelq
qhdvaqgqwdpadpapsalgsadllvcncavaalgdpasalsnmvaalreggflllhtll
rghplgdivafltstepqygqgilsqdaweslfsrvslrlvglkksfygstlflcrrptp
qdspiflpvddtsfrwveslkgiladedsarpvwlkaincatsgvvglvnclrrepggnr
lrcvllsnlsstshvpevdpgsaelqkvlqgdlvmnvyrdgawgafrhflleedkgsktf
cpahksyiiagglggfglelaqwliqrgvqklvltsrsgirtgyqakqvrrwrrqgvqvq
vstsnisslegargliaeaaqlgpvggvfnlavvlrdgllenqtpeffqdvckpkysgtl
nldrvtreacpeldyfvvfssvscgrgnagqsnygfansamericekrrheglpglavqw
gaigdvgilvetmstndtivsgtlpqrmasclevldlflnqphmvlssfvlaekhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4pivA (A:)
mqvpilekfcftphteegclseraalqeelqlckglvqalqtpsqqelprllsaacrlaq
vlaqerpklpedpllsglldspalkacldtavenmpslkmkvvevlaghghlysripgll
sphpllqlsytatdrhpqaleaaqaelqqhdvaqgqwdpadpapsalgsadllvcncava
algdpasalsnmvaalreggflllhtllrghplgdivafltsqgilsqdaweslfsrvsl
rlvglkksfygstlflcrrptpqdspiflpvddtsfrwveslkgiladedsarpvwlkai
ncatsgvvglvnclrrepggnrlrcvllsnlsstshvpevdpgsaelqkvlqgdlvmnvy
rdgawgafrhflleedsktfcpahksyiiagglggfglelaqwliqrgvqklvltsrsgi
rtgyqakqvrrwrrqgvqvqvstsnisslegargliaeaaqlgpvggvfnlavvlrdgll
enqtpeffqdvckpkysgtlnldrvtreacpeldyfvvfssvscgrgnagqsnygfansa
mericekrrheglpglavqwgaigdvgilvetndtivsgtlpqrmasclevldlflnqph
mvlssfvlae

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4pivB (B:)
mqvpilekfcftphteegclseraalqeelqlckglvqalqtkvtqqglkmvvpgldgaq
iprdpsqqelprllsaacrlqlngnlqlelaqvlaqerpklpedpllsglldspalkacl
dtavenmpslkmkvvevlaghghlysripgllsphpllqlsytatdrhpqaleaaqaelq
qhdvaqgqwdpadpapsalgsadllvcncavaalgdpasalsnmvaalreggflllhtll
rghplgdivafltstepqygqgilsqdaweslfsrvslrlvglkksfygstlflcrrptp
qdspiflpvddtsfrwveslkgiladedsarpvwlkaincatsgvvglvnclrrepggnr
lrcvllsnlsstshvpevdpgsaelqkvlqgdlvmnvyrdgawgafrhflleedkgsktf
cpahksyiiagglggfglelaqwliqrgvqklvltsrsgirtgyqakqvrrwrrqgvqvq
vstsnisslegargliaeaaqlgpvggvfnlavvlrdgllenqtpeffqdvckpkysgtl
nldrvtreacpeldyfvvfssvscgrgnagqsnygfansamericekrrheglpglavqw
gaigdvgilvetmstndtivsgtlpqrmasclevldlflnqphmvlssfvlaekhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4pivB (B:)
qvpilekfcftphteegclseraalqeelqlckglvqalqtpsqqelprllsaacrlqaq
vlaqerpklpedpllsglldspalkacldtavenmpslkmkvvevlaghghlysripgll
sphpllqlsytatdrhpqaleaaqaelqqhdvaqgqwdpadpapsalgsadllvcncava
algdpasalsnmvaalreggflllhtllrghplgdivafltsgqgilsqdaweslfsrvs
lrlvglkksfygstlflcrrptpqdspiflpvddtsfrwveslkgiladedsarpvwlka
incatsgvvglvnclrrepggnrlrcvllsnlsstshvpevdpgsaelqkvlqgdlvmnv
yrdgawgafrhflleedsktfcpahksyiiagglggfglelaqwliqrgvqklvltsrsg
irtgyqakqvrrwrrqgvqvqvstsnisslegargliaeaaqlgpvggvfnlavvlrdgl
lenqtpeffqdvckpkysgtlnldrvtreacpeldyfvvfssvscgrgnagqsnygfans
americekrrheglpglavqwgaigdvgilvetdtivsgtlpqrmasclevldlflnqph
mvlssfvlae