PDB entry 4phu

View 4phu on RCSB PDB site
Description: crystal structure of human gpr40 bound to allosteric agonist tak-875
Deposited on 2014-05-07, released 2014-07-16
The last revision was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.33 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Free fatty acid receptor 1,Lysozyme
    Species: Homo sapiens [TaxId:9606]
    Gene: FFAR1, GPR40
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14842 (13-223)
      • engineered mutation (54)
      • engineered mutation (100)
      • engineered mutation (115)
      • engineered mutation (214)
      • linker (224-225)
    • Uniprot P00720 (226-385)
      • engineered mutation (278)
      • engineered mutation (321)
      • linker (386-387)
    • Uniprot O14842 (388-End)
  • Heterogens: 2YB, OLC, 1PE, DMS, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4phuA (A:)
mdykddddkgsatmdlppqlsfglyvaafalgfplnvlairgataharlrltpsavyaln
lgcsdllltvslplkavealasgawplpaslcpvfavahfaplyagggflaalsaarylg
aafplgyqafrrpcyswgvcaaiwalvlchlglvfgleapggwldhsntslgintpvngs
pvcleawdpasagparfslslllfflplaitafcfvgclralargsnifemlrideglrl
kiykdtegyytigighlltkspslnaakseldkaigrntngvitkdeaeklfnqdvdaav
rgilrnaklkpvydsldavrraalinmvfqmgetgvagftnslrmlqqkrwdeaavnlak
srwynqtpnrakrvittfrtgtwdaygslthrrklraawvaggalltlllcvgpynasnv
asflypnlggswrklglitgawsvvlnplvtgylgrgpglktvcaartqggksqkaenly
fqghhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >4phuA (A:)
mdlppqlsfglyvaafalgfplnvlairgataharlrltpsavyalnlgcsdllltvslp
lkavealasgawplpaslcpvfavahfaplyagggflaalsaarylgaafppcyswgvca
aiwalvlchlglvfgleapggwldhsntslgintpvngspvcleawdpasagparfslsl
llfflplaitafcfvgclralargsnifemlrideglrlkiykdtegyytigighlltks
pslnaakseldkaigrntngvitkdeaeklfnqdvdaavrgilrnaklkpvydsldavrr
aalinmvfqmgetgvagftnslrmlqqkrwdeaavnlaksrwynqtpnrakrvittfrtg
twdaygslthrrklraawvaggalltlllcvgpynasnvasflypnlggswrklglitga
wsvvlnplvtgylg