PDB entry 4pf9

View 4pf9 on RCSB PDB site
Description: crystal structure of insulin degrading enzyme complexed with inhibitor
Deposited on 2014-04-28, released 2015-06-17
The last revision was dated 2015-08-26, with a file datestamp of 2015-08-21.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Insulin-degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Gene: IDE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14735
      • engineered mutation (79-80)
      • engineered mutation (140)
      • engineered mutation (147)
      • engineered mutation (226)
      • engineered mutation (383)
      • engineered mutation (542)
      • engineered mutation (559)
      • engineered mutation (758)
      • engineered mutation (781)
      • engineered mutation (788)
      • engineered mutation (873)
  • Chain 'B':
    Compound: Insulin-degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Gene: IDE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14735
      • engineered mutation (79-80)
      • engineered mutation (140)
      • engineered mutation (147)
      • engineered mutation (226)
      • engineered mutation (383)
      • engineered mutation (542)
      • engineered mutation (559)
      • engineered mutation (758)
      • engineered mutation (781)
      • engineered mutation (788)
      • engineered mutation (873)
  • Heterogens: 2Q6, ZN, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4pf9A (A:)
mghhhhhhgramnnpaikrignhitkspedkreyrglelangikvllisdpttdkssaal
dvhigslsdppniaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyy
fdvshehlegaldrfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgn
pkhpfskfgtgnkytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnl
vvklfsevenknvplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnp
ghylghlighegpgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvedi
ilhmfqyiqklraegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevl
taeylleefrpdliemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevi
kkwqnadlngkfklptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflp
kanlnfeffspfayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmyls
vkgyndkqpillkkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllm
tevawtkdelkealddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtli
ehahtkpllpsqlvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflel
faqiisepafntlrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitm
eksiedmteeafqkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylkt
ltkediikfykemlavdaprrhkvsvhvlaremdsnpvvgefpaqndinlsqapalpqpe
viqnmtefkrglplfplvkphinfmaakl

    Sequence, based on observed residues (ATOM records):
    >4pf9A (A:)
nnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppn
iaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegal
drfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgn
kytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenkn
vplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghligheg
pgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklr
aegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpd
liemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkf
klptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspf
ayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpill
kkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelke
alddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsq
lvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafnt
lrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeaf
qkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyke
mlavdaprrhkvsvhvlaremdsdinlsqapalpqpeviqnmtefkrglplfplvkphi

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4pf9B (B:)
mghhhhhhgramnnpaikrignhitkspedkreyrglelangikvllisdpttdkssaal
dvhigslsdppniaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyy
fdvshehlegaldrfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgn
pkhpfskfgtgnkytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnl
vvklfsevenknvplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnp
ghylghlighegpgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvedi
ilhmfqyiqklraegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevl
taeylleefrpdliemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevi
kkwqnadlngkfklptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflp
kanlnfeffspfayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmyls
vkgyndkqpillkkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllm
tevawtkdelkealddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtli
ehahtkpllpsqlvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflel
faqiisepafntlrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitm
eksiedmteeafqkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylkt
ltkediikfykemlavdaprrhkvsvhvlaremdsnpvvgefpaqndinlsqapalpqpe
viqnmtefkrglplfplvkphinfmaakl

    Sequence, based on observed residues (ATOM records):
    >4pf9B (B:)
npaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppni
aglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegald
rfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgnk
ytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenknv
plpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghlighegp
gsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklra
egpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpdl
iemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkfk
lptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspfa
yvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpillk
kiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelkea
lddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsql
vryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafntl
rtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeafq
khiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfykem
lavdaprrhkvsvhvlaremdslsqapalpqpeviqnmtefkrglplfplvkphin