PDB entry 4pf3

View 4pf3 on RCSB PDB site
Description: Mineralocorticoid receptor ligand-binding domain with compuond 37a
Class: transcription/transcription inhibitor
Keywords: NUCLEAR RECEPTOR, TRANSCRIPTION FACTOR, HYPERTENSION, NON-STEROIDAL ANTAGONIST, ACTIVATING MUTATION, TRANSCRIPTION-TRANSCRIPTION INHIBITOR complex
Deposited on 2014-04-28, released 2014-11-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-22, with a file datestamp of 2020-01-17.
Experiment type: XRAY
Resolution: 1.1 Å
R-factor: N/A
AEROSPACI score: 0.74 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mineralocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR3C2, MCR, MLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08235
      • engineered mutation (98)
      • engineered mutation (100)
      • engineered mutation (266)
    Domains in SCOPe 2.08: d4pf3a_
  • Heterogens: HFN, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4pf3A (A:)
gsapakepsvntalvpqlstisraltpspvmvleniepeivyagydsskpdtaenllstl
nrlagkqmiqvvkwakvlpgfknlpledqitliqyswmsllsfalswrsykhtnsqflyf
apdlvfneekmhqsamyelcqgmhqislqfvrlqltfeeytimkvllllstipkdglksq
aafeemrtnyikelrkmvtkcpnnsgqswqrfyqltklldsmhdlvsdllefcfytfres
halkvefpamlveiisdqlpkvesgnvkplyfhrk

    Sequence, based on observed residues (ATOM records): (download) 
    >4pf3A (A:)
tpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvlpgfknlp
ledqitliqyswmsllsfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhq
islqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvtkcpnns
gqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvesg
nvkplyfhr